Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 166 for “"functionalisation"”.
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Selective Protein Functionalisation at Methionine
… of novel bioconjugation strategies for the functionalisation of polypeptides and proteins has been of great benefit to the fields of chemical biology and medicine. Selective protein functionalisation has enabled the development of technologies such as targeted drug delivery, enzyme activity …
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Metal-free C-H functionalisation methods
… describes the development of two metal-free C–H functionalisation methods which encompass oxidations of sp³- and sp²-hybridised C–H bonds.Chapter 1 provides a brief introduction to the rapidly growing area of C–H functionalisation and outlines selected metal-catalysed and metal-free C–H …
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Hypervalent iodine reagents for protein functionalisation
… and more sensitive methods for protein functionalisation. Subsequently, we describe the N-arylation of hydroxylamine in peptide substrates using diaryliodonium salts in the presence of a base. This technique is rapid and tolerates water, but has only been demonstrated on small molecules. …
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Surface functionalisation techniques for colloidal inorganic nanocrystals
… amphiphilic polymers for water transfer and functionalisation of nanocrystals are synthesised, characterised and tested. Commercially-available polymers used for this purpose are examined, leading to a rationale for custom-design. Partial water transfers were achieved using activated ester …
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Surface Functionalisation and Characterisation of Cellulose Nanocrystals
… reagent, carboxylic acids are key. Here, the functionalisation of CNCs with the conductive polymer PEDOT and with an amine-terminated polyether were both attempted. Moreover, to understand the results of these attempted functionalisation reactions, characterisation of the targeted surface …
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Direct ⍺-C–H Functionalisation of Cyclic Alkylamines
… Consequently, methods for the selective functionalisation of these scaffolds would greatly facilitate the optimisation of biological activity, physicochemical properties and the systematic evaluation of structure-activity relationships. This thesis describes efforts towards the development …
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Synthesis, Characterisation and Functionalisation of CdSe Quantum Dots
To date, quantum dots (QDs) have been synthesized through a number of different processes ranging from colloidal synthesis to electrochemical methods to chemical vapour deposition (CVD). This thesis focuses on the synthesis of high-quality CdSe nanocrystals through a bench- top colloidal synthesis …
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Peptide functionalisation and characterisation of gold (nano) surfaces
… overview of the design considerations, routes to functionalisation and characterisation techniques which must be taken into account when developing such materials. 3.0 describes the development of a method for the step-wise functionalisation of planar gold surfaces with short peptide derivatives, …
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Modified oligonucleotides for the functionalisation of nanoscale materials
… was to develop a novel ligand for biomolecular functionalisation with a view to enhancing the stability of oligonucleotide-nanoparticle conjugates and assessing the suitability of a nanostructured surface for the detection of hybridisation events by surface enhanced resonance Raman scattering …
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Colloidal Self-Assembly: Particle Synthesis, Functionalisation and Applications
Colloids, broadly defined as particles small enough to not sediment under gravitational force while dispersed in a continuous medium, are of great scientific and industrial importance. They are present in foods, cosmetics, paints and other materials, often in a jammed or a gelled state. This …
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Planning And Interpretation Of Late Stage Functionalisation Reactions
… in a fast and efficient manner. Late stage functionalisation (LSF) is poised to accelerate the process by making chemical synthesis modular so most of the molecules are assembled via standard protocols. Predicting the major reaction site is not straightforward due to multitude of competing …
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Exploring the synthesis and functionalisation of methano[10]annulene
Within medicinal chemistry, there is always effort to strive for more effective drug molecules. One method to achieve this is through bioisosteres. Bioisosteres are “groups or molecules which have chemical and physical similarities producing broadly similar biological effects”. For this thesis, the …
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Functionalisation of polymers: reactive processing, structure and performance characteristics
The main aim of this work was to study the effect of two comonomers, trimethylolpropane trimethacrylate (TRIS) and divinylbenzene (DVB) on the nature and efficiency of grafting of two different monomers, glycidyl methacrylate (GMA) and maleic anhydride (MA) on polypropylene (P) and on natural …
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Radical functionalisation of amino acid derivatives / by Katherine Kociuba.
Erratum pasted facing title page.
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Spectroelectrochemical, Separation and Surface Functionalisation Studies of Plasmonic Nanoparticles
… nanoparticle shape control and future functionalisation. Overall, the approaches studied in this thesis demonstrate the successful control of the properties of plasmonic nanoparticles and support future research directions towards realising the rich potential of their applications.
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Surface Functionalisation of Metal-Organic Frameworks for Biomedical Applications
… highlights the critical role of external surface functionalisation of nanoparticles in addressing the current challenges posed by antimicrobial resistance and cancer.
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Plasmachemical Functionalisation for Modification of Surfaces with Biomolecules and Metals
Plasmachemical functionalisation offers a versatile route to surface functionalisation, allowing a wide variety of functional groups to be deposited in a substrate independent process. This thesis presents the application of pulsed plasmachemical functionalisation in two areas. Firstly, the …
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Synthesis, functionalisation and characterisation of germanium nanocrystals & their applications
In the last two decades, semiconductor nanocrystals have been the focus of intense research due to their size dependant optical and electrical properties. Much is now known about how to control their size, shape, composition and surface chemistry, allowing fine control of their photophysical and …
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Synthesis and functionalisation of metal and metal oxide nanoparticles for theranostics
Metal and metal oxide nanoparticles including calcium oxide, gold, and superparamagnetic iron oxide nanoparticles (SPIOs) were synthesised using a range of techniques including reduction, co-precipitation and spinning disc technology. SPIOs were primarily synthesised via a co-precipitation method …
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