Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"functional similarity"”.
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Functional Similarity of Prd-Containing Virulence Regulators In Bacillus Anthracis
<p><em>Bacillus anthracis </em>produces three regulators, AtxA, AcpA, and AcpB, that control virulence gene expression and are members of an emerging class of regulators termed “PCVRs” (Phosphoenolpyruvate-dependent phosphotransferase regulation Domain-Containing Virulence Regulators). AtxA …
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New Methodology for Measuring Semantic Functional Similarity Based on Bidirectional Integration
… and Statistical Mean (BSM) score to calculate functional similarity between gene products (GPs) that can help to extract biologically relevant and statistically robust information from large-scale biomedical, genomic and proteomic data sources. BSM score is defined by 16 different scoring …
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Recombinant Hemoglobin Variants: Structure-Function Analysis and Oxygen Therapeutic Design
… polymerized hemoglobin. The clear structural and functional similarity of these variants to native hemoglobin and improved vascular stability suggests that they have potential for use as an oxygen carrying therapeutic.
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Incorporating diverse data to improve genetic network alignment with IsoRank
… and chromosome localization data to improve the functional similarity of aligned genes. Alignments are evaluated with consistency measurements of protein function within ortholog clusters, and with an information-retrieval statistic from a small set of known orthologs. Integrating these …
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Towards Biologically Plausible Deep Neural Networks
… explore whether deep neural networks with high functional similarity measures can provide reliable insights into the architectural building blocks of the brain.
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Role of communication between subunits and enzymes in ClpXP-mediated substrate unfolding and degradation
… ClpXP, a molecular machine with structural and functional similarity to the eukaryotic 26S proteasome. ClpXP consists of hexameric ClpX rings stacked coaxially against the double-ring ClpP₁₄ peptidase. ClpXP's peptidase active sites reside in a sequestered chamber accessible through a narrow …
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Characterizations of how neural networks learn
… distance between two models that captures their functional similarity, and (b) a distillation algorithm to efficiently extract interpretable decision-tree structure from a trained model when possible.
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Assessing Impacts of Digital Sketching on Concept Generation in Early Stage Design
… for design prompts that had more than one functional requirement since not all ideas addressed all parts of the design prompt. However, for these prompts, the results from the primary functional requirement exhibited the same concept chaining patterns with more chaining present for tablet …
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Defining the functional role of MAGE-C1 in Multiple Myeloma
… 1 (RBX1), was confirmed in RPMI-8662. Next, functional similarity was investigated through co-immunoprecipitation, to determine MAGE-C1 interaction with RBX1 or SKIP, and immunofluorescence microscopy, to assess co-localisation of these proteins. Lastly, cellular pathways influenced by …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… an ortholog with significant sequence and likely functional similarity is identified in the related parasite Globodera pallida, which causes an identical disease in other major agricultural crops including potato and tomato plants and exhibits the same arrest phenotype inside the egg as H. …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… an ortholog with significant sequence and likely functional similarity is identified in the related parasite Globodera pallida, which causes an identical disease in other major agricultural crops including potato and tomato plants and exhibits the same arrest phenotype inside the egg as H. …
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A Semantic Approach for Automatic Recovery of Software Architecture
… repository. It leverages the information such as functional similarity between code entities (e.g. classes) and applies a machine learning technique to cluster source code into architecture components – an essential activity in architecture recovery. Specifically, the approach includes three …
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Methods for Analysis of Prokaryotic Genome Architecture
… effective at characterizing groups of organisms. Functional motifs can help explain the organizing principles behind cellular systems in bacteria which have yet to be well understood. Currently there are relatively few bioinformatic tools for analyzing potential patterns at the level of genome …
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The Structural and Functional Analysis of a Voltage-Dependent Potassium Channel
… through crystallographic, biochemical and functional studies of KvAP, a voltage-dependent K<sup>+</sup>(Kv) channel from a thermophilic archeabacterium. I show that KvAP channels possess all the functional properties of eukaryotic Kv channels responsible for nerve impulses. This functional …
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A domain-general perspective on medial frontal brain activity during performance monitoring
… from a frequently executed response). The functional significance of MFNs has traditionally been interpreted in the context of the paradigm used to elicit a specific response, such as errors. In a series of studies, we consider the functional similarity of multiple MFC brain responses by …
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Descending premotor target tracking systems in flying insects
… predatory and nonpredatory dipterans, finding functional similarity of these neurons for prey capture and conspecific pursuit. Dipteran TSDN responses are repressed by background motion in a direction dependent manner, suggesting a control architecture in which target tracking and optomotor …
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Integrative analysis of heterogeneous genomic datasets to discover genetic etiology of autism spectrum disorders
… that disease-causing genes have some sort of functional similarity based on either sequence, phenotype, protein-protein interaction (PPI) network, or functional annotation. Another increasingly accepted view is that human diseases result from perturbations of molecular networks, and genes …
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Community ecology of aquatic insects in forested headwater streams in the southern Appalachians
… by locally selecting colonizers with similar functional traits, whereas dispersal assembly emphasizes the importance of source pool characteristics and dispersal limitation in organizing a metacommunity. In this study, I developed a framework that uses spatially explicit patterns in taxonomic …
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The chemistry and evolution of enzyme function: isomerases as a case study
… Last, the relationship between sequence and functional similarity suggests that correlations should be investigated on the basis of closely related enzymes. Although previous research assumes a one-to-one relationship between EC number and biochemical reaction, almost one-third of all known …
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Mining common genetic Variants impacting on Allele-Specific Translation and cancer risk
… to identify tranSNPs and validate their functional consequences. Two case studies, rs1053639 in the DDIT4’s 3’UTR and rs1554710467 in eIF4H’s coding sequence, highlight the effectiveness of this approach in uncovering cis regulators of allele-specific translation. The first study focuses …
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