Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"functional selectivity"”.
-
FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… responses provide opportunities for biased or functionally selective ligands to preferentially modulate one signaling pathway over another. Studies with several GPCRs have suggested that selective activation of signaling pathways downstream of a GPCR may lead to safer and more effective drug …
-
Action-related organization of object representations in human visual cortex and topographic models
… (OTC) are organized by multiple spatial and functional principles, including category-selective areas and large-scale topographic maps structured by properties such as animacy and real-world size. In parallel, recent work has proposed a functional dissociation within OTC, with a ventral …
-
Large-scale production and characterization of an engineered human olfactory receptor
… soluble molecules. However, the structural and functional mechanisms of these amazing receptors are not currently known. In order to begin to investigate the molecular mechanism(s) of olfaction, I have developed a mammalian expression system for the large-scale production and purification of …
-
Super-aptamer bio-imprinted hydrogels : an investigation into the optimization and characterization of cross-linked polymeric materials displaying macromolecular amplified responses
… techniques and materials aimed at increasing the selectivity of artificial binding sites based of improved shape, size, or functional selectivity both as a function of bulk polymer matrix and functional receptor molecules located in the active site. Here, a new type of aptamer-based hydrogel with …
-
Development and Characterization of Selective CB2R Inverse Agonists as a Novel Anti-Inflammatory Therapy for Neuroinflammation – Mechanisms of Action in Murine and Human Microglia Models Provide Valuable Insights into Their Therapeutic Potential
… and evaluated in ACTOne and TANGO-bla functional assays for CB1 and CB2 activity in combination with affinity measurements for the CB1/2 receptors. Moreover, the compounds that demonstrated no activity at functional assays with high binding affinities to CB2R were further assessed in …
-
An Investigation into the pharmacology of the ghrelin receptor
… efficacies to that of ghrelin, demonstrating functional selectivity at the GRLN-R. Intact cell assays were also used to measure Gaq/11 and Gai/o responses, however, a Gai/o-mediated response could not be measured in cAMP accumulation assays, suggesting that the GRLN-R could signal via …