Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 422 for “"functional role"”.
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Functional role of ZAP70 in Chronic Lymphocytic Leukaemia
… of CLL. In this study, I investigated the role of ZAP70 in CLL. This was done using P505-15, a dual selective SYK and ZAP70 inhibitor, to reduce kinase activity of ZAP70. This was followed by siRNA knockdown experiments to disentangle effects of SYK and ZAP70 and reduce off target effects …
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Functional role of neurotransmitters in the visual thalamus
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1991.
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FUNCTIONAL ROLE OF NON-CODING REGULATORY VARIANTS IN NEUROBLASTOMA
… can contribute to disease, mainly by residing in functional regulatory regions and ultimately affecting gene expression networks. However, their interpretation is challenging. In our recent work, whole-genome sequencing (WGS) data from 151 neuroblastoma primary tumours identified two clusters of …
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Functional role of plant water fluxes in nutrient acquisition
Transpiration is inevitable during photosynthesis; however, it may also function to cool leaves, transport nutrients and drive nutrient acquisition via mass-flow. In addition to transpiration, plants water fluxes occur through hydraulic redistribution (HR). I hypothesized that an important function …
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Functional role of NMDA receptor subunit composition in metaplasticity
… in visual cortex. We provide evidence for the functional significance of the NR2A subunit in metaplastic changes both in synaptic platicity elicited in vitro and in naturally-occurring platicity in vivo. We also performed a comparison of in vitro methods of inducing plasticity and those which …
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The Functional Role of Anatomical Feedback Connections In Visual Attention
… on the purpose of these signals. However, the functional role of feedback connections remains a mystery, despite their sheer abundance and prevalence when compared to feedforward connections. The field has long hypothesized that feedback acts as a conduit for attentional signals, carrying them …
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Expression and functional role of cyclooxygenase enzymes in cervical carcinoma
… the expression, localisation and possible functional role of cyclooxygenase enzymes in cervical carcinomas. The initial aim of the study was to determine whether cyclooxygenase-1 and cyclooxygenase-2 expession and prostglandin E₂ synthesis are up-regulated in cervical cancers. Real-time …
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Defining the functional role of MAGE-C1 in Multiple Myeloma
… to lack of knowledge regarding their pathogenic role. To start elucidating the function of melanoma antigen (MAGE) protein-C1 (MAGE-C1) in multiple myeloma, this project aimed to firstly establish the suitability of culture cell line RPMI-8226 as an in vitro multiple myeloma model. Additionally, …
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The functional role of tectorial membrane poroelasticity in cochlear mechanics
… long been accepted that the TM plays a critical role in the stimulation of sensory hair cells. Early measurements demonstrated elastic properties of the TM and suggested that the TM is resonant. More recent measurements have shown that longitudinal coupling of the TM generates traveling waves …
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… Inhibitors to GSK3β and p38MAPK verified their roles. GSK3β inactivation was associated with nuclear translocation of antioxidant nuclear factor erythroid 2–related factor 2 (Nrf2) and exosomal section of β-catenin. OS-induced P-p38MAPK activation is associated with functional down regulation of …
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The Functional Role of the Anterior Insular Cortex in Cognitive Control
… as one of its key structures. However, the functional role of the AIC in cognitive control has not been fully understood. A human lesion study was conducted to examine the necessary function of the AIC in cognitive control. A mouse optogenetic study with fiber photometry recording further …
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Functional Role of Hepatitis B Virus Core Protein in Viral Replication
PART I To investigate the contributions of carboxyl-terminal nucleic acid binding domain of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for …
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Study of the Functional Role of ATP1A3A in the Vertebrate Nervous System
Na+, K+ ATPases are a group of transmembrane-bound pumps found in all animal cell types. The primary functions of Na+, K+ ATPases are to maintain electrochemical gradients across cell membranes by actively transporting Na+ and K+ ions between intracellular and extracellular spaces using ATP …
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THE FUNCTIONAL ROLE OF ASTERIAS VULGARIS VERRILL (1866) IN THREE SUBTIDAL COMMUNITIES
<p>The functional role of Asterias vulgaris has been investigated in three subtidal communities at the Isles of Shoals, New Hampshire, U.S.A., from 1975 to 1980. The three communities are located at depths of 8 m, 18 m, and 30 m along a transect from the intertidal to a depth of 35 meters on rocky …
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NAC transcription factors in sugarcane and their functional role in drought tolerance
… the surviving transgenic plantlet, leaving the role of VuNAC1 in sugarcane development and stress tolerance unresolved. Interest in the mechanisms by which VuNAC1 improved transgenics’ performance motivated the search for functionally similar NAC genes in sugarcane. Database and phylogenetic …
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