Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"functional repair"”.
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Tissue engineering with glial cells and a novel biodegradable matrix to promote functional repair following experimental spinal cord injuries
… third and final part of the thesis addresses the functional consequences of implanting the matrix into acutely spinal cord injured rats. A clear and statistically significant improvement of food pellet retrieval was demonstrated by the objective “staircase test”. The data are discussed in the …
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Investigations into the Ulnar Response to Mechanical Stimuli Activating Lamellar and Woven Bone Formation
… triggers a woven bone response that leads to a functional repair of whole-bone strength. Overall, the work done in this thesis has enhanced our understanding of bone formation. Future studies will expand on the microarray findings and clarify the role of angiogenesis in woven bone formation.
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Development and Validation of Large-Sized Engineered Cartilage Constructs in Full –Thickness Chondral Defects in a Rabbit Model
… of current surgical interventions for the repair of articular cartilage is jeopardized by the formation of mechanically inferior repair tissue. Cartilage tissue engineering offers the possibility of developing functional repair tissue, similar to that of native cartilage, enabling …
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Bioactive Poly(Lactic-co-Glycolic Acid)-Calcium Phosphate Scaffolds for Bone Tissue Regeneration
… grafting. Autologous grafts may achieve functional repair; yet, they are available in limited supply and are associated with donor site morbidity. Allogeneic grafts are available in greater supply, but have a higher risk of infection. To overcome the disadvantages of current grafts, …
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Studies of plasticity after neuronal injury
… is often poor, leading to a suboptimal functional outcome. In contrast, injured CNS neurons have a poor growth response and completely fail to regenerate, but uninjured axons that survive the injury undergo some degree of spontaneous reorganisation that is accompanied by limited …
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Characterising changes in pathology and function in clinically relevant models of spinal cord injury and using chondroitinase ABC gene therapy to promote repair
… ChABC has repeatedly been shown to enhance functional recovery in a number of SCI models in both rodents and larger animals through its enzymatic degradation of inhibitory chondroitin sulphate proteoglycans (CSPGs). However, ChABC treatment has met with limited success in more traumatic, …
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ROLES OF INOSITOL DIPHOSPHATES IN DNA REPAIR AND EFFECTS OF ASPIRIN ANALOGUES ON OESOPHAGEAL CANCER
… One such role it is often associated with is DNA repair. The DNA repair process following DNA insult is considered crucial for the genomic integrity and stability. Failure to perform this task will result in mutations and possibly disease. Thus, it is important that we expand our knowledge on how …