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Showing 1 to 3 of 3 for “"functional mutants"”.
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Nmr Solution Structures Of Two Hairpins Of E. Coli 16s Rrna: The Effects Of Mutations And Chemical Modifications On Structure And Function Of Rrna
<p>The structures of two functional mutants, the UC (G690U, U697C) and the QM mutants (G690A, G693C, A695C, U697A) of the 690 hairpin of E. coli 16S ribosomal RNA were determined by NMR. The UC mutant and the QM mutant with high biological function are able to fold into structures that are …
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Genetic and biochemical analysis of a conserved DEAD-box helicase motif
… of a novel, high-throughput approach to identify functional mutants of motif Va and individual amino acids that are crucial for Mss116p function. We use in vitro assays to further dissect the effects of mutating a highly-conserved motif Va residue, showing that motif Va plays an important role in …
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Study Of Protein-Rna Interactions Using Fluorescence Resonance Energy Transfer (fret) And Single-Molecule Fret
… catalytic and regulatory roles. Despite their functional importance, the mechanistic details and dynamics of RNPs are poorly understood. Single-molecule Fluorescence Resonance Energy Transfer (smFRET) techniques that provide information about heterogeneity and dynamic behaviors of molecules …