Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"functional heterogeneity"”.
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Functional Heterogeneity of Fibroblasts In Dermal Wound Healing
… origins and heterogeneous functions. Fibroblast heterogeneity is in part exemplified by the numerous expression markers used to distinguish them. The overarching goal of this study is to precisely define the heterogeneity of dermal fibroblasts and unravel their functional roles during cutaneous …
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
… This is partly due to the considerable heterogeneity amongst these cells, which confounds the characterization of their roles within the tumor microenvironment. Nevertheless, recent studies have provided fresh insights in CAFs biology and how these cells contribute to tumorigenesis at …
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Structural and functional heterogeneity of cells in the rat hippocampus
Memory is encoded in the structure and function of the hippocampus. The laminar structure and organization of information flow are well established. The dentate gyrus (DG) is the initial layer that receives and parses incoming signals. The signal is then transmitted to the CA3 and subsequently the …
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Computational Approaches to Delineate Transcriptional and Functional Heterogeneity In Pancreatic Cancer
… advancements in next generation sequencing and functional genomics, we have sought to establish computational methodologies to aid in refined target discovery, and to develop a novel platform to comprehensively characterize the transcriptional heterogeneity of PDAC. Specifically, focusing on a …
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Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous system
… single-cell Drop-sequencing uncovered a heterogeneity of oligodendrocyte (OL) subpopulations in the motor cortex. Whilst some OL subpopulations are of mixed developmental origin, others are exclusively formed by either ventrally or dorsally derived OLs, arguing that dorsal oligodendrocyte …
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Dissecting the Functional Heterogeneity of Serotonergic Systems That Regulate Fear and Panic
Serotonin (5-HT) is heavily implicated in severe anxiety and trauma-related disor-ders, such as panic and post-traumatic stress disorders. Overall, site-specific pharmacolog-ical manipulations show that while 5-HT enhances anxiety-associated/avoidance behaviors in the amygdala, 5-HT inhibits …
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The role of high density lipoprotein compositional and functional heterogeneity in metabolic disease
… HDL have been shown to possess a wide variety of functional attributes which likely contribute to this protection including anti-inflammatory and anti-oxidative properties and the ability to remove excess cholesterol from peripheral tissues and deliver it to the liver for excretion, a process …
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Strain-resolved transcriptomics: exploring functional heterogeneity of the gut microbiota in health and disease
… yet current analyses treat bacterial species as functionally uniform, ignoring extensive strain-level diversity that may drive disease mechanisms. Here, we developed a strain-resolved metatranscriptomics framework to investigate how transcriptional activity varies across bacterial lineages and …
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The Role of Map Kinases On The Functional Heterogeneity of Human Cd8+ T Cell Maturation Subsets
… therefore they do not co-produce IL-2/IFNγ (polyfunctionality), which has been shown to be critical for protective immunity against chronic viral infection. These data suggest that late memory CD8+ T cells are not just cytotoxic effectors, but may have unique functional properties. Determining …
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Cellular Immunity in Hamsters After Immunization With Vaccinia Virus: Studies on Macrophage Functional Heterogeneity and Interactions Between Natural Killer Cells and Macrophages
This study demonstrated that macrophage (M(phi)) subpopulations can be isolated from normal and vaccinia virus-immune peritoneal exudate cells after separation on bovine serum albumin (BSA) discontinuous density gradients. The M(phi) subpopulations from normal and early- or late-immune animals were …
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Computational Approaches to Understand Chemoresistance & Tumor Evolution Using Longitudinal Clinical Data and Lineage Tracing
… cell sequencing has enabled us to anatomize the heterogeneity further and provide evidence of its association with chemo and drug resistance. To investigate this further we took two different approaches to understand the chemo-resistance, and functional heterogeneity in Triple negative breast …
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Macrophage differentiation: A heterogeneous theory
"Functional heterogeneity of macrophage populations has been characterized however, questions remain regarding the mechanisms underlying the development of this heterogeneity. A procedure was developed to molecularly phenotype colonies of bone marrow-derived macrophage(s) (BMDM). Gene expression …
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Quantifying T cell Mediated Killing for Melanoma Immunotherapy
… still result in a wide range of outcomes. Functional heterogeneity, at the single-cell level, of cells infused for ACT has not been routinely characterized and consequently their efficacy and persistence in vivo following ACT are unpredictable. By using a high-throughput single-cell …
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Prenatal Environmental Stressors Impair Postnatal Microglia Function and Adult Behavior in Males
… connectivity. When we performed in vivo functional recordings from brain networks important for social behavior, we found that only males engaging in a social preference task, had impaired activation of this network. Microglia development and microglia-synapse interactions were also …
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TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
… the structural determinants underlying the functional heterogeneity of canonical and variant assemblies remain poorly understood. In this study, all PRC1 cores were reconstituted in vitro and purified as homogeneous complexes, enabling a direct comparison of their biochemical and structural …
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Assessing the Challenges of Economic Evaluation of Critical Care Outreach Services (CCOS): A Typology Approach
… A literature review revealed structural and functional heterogeneity between CCOS in England. Yet it remained unknown how the services are configured in Wales. Numerous measures have been used to evaluate effectiveness. However, no economic evaluation has been conducted for CCOS as a whole …
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Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
… of a novel 'layer' of intrinsic non-genetic functional heterogeneity within the seemingly homogeneous naive CD8⁺ T cell population in their survival and proliferation capacities. This heterogeneity is predictably marked by the surface level of CD5. NaYve CD8⁺ T cells that are also CD5hi have …
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Transcriptional and Multi-Omic Heterogeneity in Glioblastoma Stem Cells
… have to target this population. Evidence of functional heterogeneity of GSCs at the level of the transcriptome and drug response motivates a full characterization of GSCs’ biological variation. In this project, I use multiple -omic data types from both bulk and single cell resolution to …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
… little is known about the structural and functional heterogeneity among α-Syn oligomers occurring in different diseases. Moreover, the functional crosstalk between these toxic oligomers has not been scrupulously studied. Here, by using biochemical, biophysical and cell-based techniques, I …
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New stimulators and a new mechanism of regulated secretion in pituitary gonadotropes
… only subpopulations of gonadotropes establishing functional heterogeneity of pituitary gonadotropes. On the other hand, a protein kinase C (PKC) activator--phorbol-12-myristate-13-acetate (PMA)--caused LH release from pituitary gonadotropes without evoking changes in (Ca$\sp{2+}\rbrack\sb{i}$. …
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