Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"functional genes"”.
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Profiling of Microbial Communities, Antibiotic Resistance, Functional Genes, and Biodegradable Dissolved Organic Carbon in a Carbon-Based Potable Water Reuse System
… carbon, underlying microbial populations, and functional genes are explored. Further, dynamics associated with antibiotic resistance genes (ARGs), identified as a microbially-relevant CECs, are also assessed. Overall, this dissertation advances understanding associated with the interplay …
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Microorganisms and Functional Genes Associated with Cometabolic Degradation of 1,4-Dioxane in Biologically-Active Carbon Biofilters Applied for Potable Reuse Treatment
… means of broadly profiling microbial taxa and functional genes involved in various metabolic processes. In this thesis, methods for DNA extraction from granular activated carbon applied to full-scale BAF amended with propane for the purpose of 1,4-dioxane cometabolism were optimized and …
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A metagenomic approach to understanding the relationship between the vaginal microbiome and women’s reproductive health
… sequencing to classify sequence to bacteria and functional genes in microbial samples from 38 Chinese women with and without BV from 20 to 52 years (means ± SEM 35.6 ± 1.2 years). The samples were collected by swabs from cervix, middle, and upper vagina walls. Elevated sialidase activity (>= …
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The effects of natural selection on human Y chromosome amplicons
… pressures that caused the loss of most of its genes. Because of this lack of functional genes, speculation abounded that natural selection is ineffective on a chromosome that lacks a homolog with which to recombine, and that the Y chromosome is doomed to eventually fade away. In recent years, …
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Fundamental and Practical Aspects of Cometabolite Addition for 1,4-Dioxane Removal in Biofiltration
… removal in the BAC. Further analysis of functional genes implicated that a soluble methane monooxygenase, part of a family of functional enzymes called soluble diiron monooxygenase (SDIMO), was the most important enzyme for cometabolic propane and 1,4-dioxane degradation. The enzyme's …
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Patterns, Processes And Models Of Microbial Recovery In A Chronosequence Following Reforestation Of Reclaimed Mine Soils
… taxonomic composition, interaction patterns and functional genes. Generally, microbial succession followed a trajectory along the chronosequence age, with communities becoming more similar to reference sites with increasing age. However, two major branches of soil microbiota, bacteria and fungi, …
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Extinction of Chromosomes due to Specialization is a Universal Occurrence
… human Y chromosome losing 97% of its ancestral genes while gene content and order remain highly conserved on the X chromosome. Five ‘stratification' events, most likely inversions, reduced the Y chromosome's ability to recombine with the X chromosome across the majority of its length and …
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Analogue enrichment of aromatic degradation through application of lignin-derived phenols
… found to have influence on the phylogenetic and functional genes of the diverse bacterial population responsible for degradation of naphthalene (and PAH other cocktails) in the PAH-contaminated urban soils. The bacterial population implicated in this study are primarily from the Proteobacteria, …
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The role of circadian rhythms in reproduction: development and fertility in the bmal1 null mouse.
… A bioinformatical evaluation of a panel of genes closely involved in reproduction and ovarian function was analysed for the presence of circadian enhancer regions (E-box sequences) or RORA response elements (RRE) in their promoter regions. It was revealed that many of the genes investigated …
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The type I IFN of Bos taurus
… expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal recognition of pregnancy in cattle. This work has two main aims 1) determine whether male and female blastocysts differ in the kind …
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Image-based pooled genetic screens for complex cellular phenotypes
… recent technologies have enabled scalable functional genomics approaches such as pooled CRISPR screening, the cellular phenotypes that can be linked to gene function in a pooled screen have been restricted to measurement by sequencing, and are often a step removed from the biological …
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Assessing genomic variation in the hopbush, Dodonaea viscosa, to investigate micro-evolution and adaptation
… then used to selectively target a subset of 970 genes via ‘hybrid-capture target enrichment’ in order to develop a set of SNP markers present within putatively functional genes distributed throughout the genome. The SNP markers were used to characterise population genomic metrics of the target …
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Investigating Rhizobium Leguminosarum Metabolism and Rhizosphere Colonization Using High-Throughput Genomics and Erythritol Enrichments
… community composition, and to discover novel genes influenced by erythritol catabolism in Rhizobium leguminosarum 3841. Microbial communities from bulk soil, and roots, and nodules of pea plants prepared in the bulk soils were enriched on general and erythritol media. Colony morphology assays …
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Management, microbiology, and machine learning: A systems approach to evaluating the nitrogen cycling microbiome in agricultural soils
… differentially influence several key N cycling functional groups. Next, I illustrate the risk of introducing Type II statistical errors to our downstream data analysis when we fail to consider the breadth of diversity represented among the functional genes we assess. I then show that …
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Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
… I compared and contrasted the structural and functional genes of CyCMV to human and rhesus macaque CMV with respect to genes involved in pathogenesis, immune evasion, species-specificity, and more. In order to maximize the ability to manipulate the virus for vaccine purposes, I cloned CyCMV as …
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Microbial Diversity and Geochemical Energy Sources of Tutum Bay, Ambitle Island, Papua New Guinea, an Arsenic-Rich, Shallow-Sea Hydrothermal System
… Finally, in chapter four, evidence of functional genes related to both arsenate- and arsenite-redox were recovered from sediments examined via molecular screening. It was also shown that microbial consortia enriched from Tutum Bay sediments and porefluids were able to reduce arsenate: …
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Characterizing the Mechanisms Regulating Enhancer Commissioning by MyoD in Muscle Cells
Myogenesis refers to the cellular process required for muscle formation and repair of damaged muscle tissue. During this process, the activation of muscle gene expression is tightly regulated to ensure efficient transitions between cell fates. This activation is promoted by large groups of …
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Nitrous oxide from denitrification: Influence of field management, environmental conditions, and nutrient availability
… Midwest and a connection between denitrification functional genes and potentials. Since denitrification was the major contributor of N2O emissions in my work, I then specifically targeted N2O emissions from denitrification to assess factors driving the N2O ratio, a measure of denitrification’s …
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Examining coral reef ecosystem dynamics using microorganisms and metabolites
… and targeted metabolomics, microbial taxa, and functional genes from metagenomics across 300 km of reefs in Florida, in addition to microorganisms in healthy and diseased corals. With this unprecedented combination of ‘omics datasets, I found that biogeographic zones, environmental features, and …
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Microbial transformation of arsenic in Bengal floodplain
… to investigate microbial composition and functional diversity of arsenic metabolism genes and how this may be related to differences in arsenic dynamics within these soils. Compared to Pleistocene soils, the Holocene soils had higher concentrations of arsenic, other elements and pore water …
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