Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 86 for “"functional domains"”.
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Functional Domains in the Multigene Regulator of the Group A Streptococcus
… overall goal of identifying and characterizing functional domains within the protein. The first section of this study uses a naturally occurring mutant, previously identified to be deficient in transcriptional activation, as a guide to map functional residues within Mga. Electrophoretic mobility …
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Genetic dissection of the functional domains of the PutA protein of Salmonella typhimurium
… and the putA gene, which encodes a multifunctional membrane-associated dehydrogenase that degrades proline to glutamate. PutA protein also autogenously regulates transcription of the put operon. The deduced amino acid sequence of PutA exhibits similarities to eukaryotic protein kinases …
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Characterization of Histone H2A Functional Domains Important for Regulation of the DNA Damage Response
… work I characterize two conserved histone H2A functional domains that are required for normal response to DNA damage. In the first part of my thesis, my collaborators and I demonstrate that Tetrahymena major histone H2A.S contains an H2A.X variant-specific SQ motif within its C-terminal tail, …
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From spatio-temporal data to a weighted and lagged network between functional domains: Applications in climate and neuroscience
… task is to identify the distinct semi-autonomous functional components of the spatio-temporal system and to infer their interconnections. In this thesis, we propose two methods that identify the functional components of a spatio-temporal system. Next, an edge inference process identifies the …
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Predictability of everyday task performance by perceived health, self-efficacy and cognitive ability
… a brief neuropsychological measure and everyday functional ability in older community dwelling adults. The association between these two areas is complex, as a specific functional domain often involves several of the cognitive skills typically assessed by a neuropsychological instrument. Whilst …
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Analytical Framework to Study Energy Efficiency Policy Portfolios across Countries/States
… The research begins with identification of the functional domains that influence human behavior–people, economy, environment and technology–followed by identification of the factors affecting household energy consumption. It uses the four functional domains as the evaluation framework's four …
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Androgen Regulation of Gene Expression Associated with Cell Growth and Neural Plasticity: Studies in Songbird Brain and the S115 Cell Line
… androgen. The sequence is very conserved over functional domains, but shows some divergence from the only other sequences known, those for rodents and man. The AR mRNA can be localized by in situ hybridization in the canary to the testis and the song nuclei HVc, RA, and MAN. The AR mRNA is …
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Chinese Englishes: History, Contexts, and Texts
The current profile of attitudinal range and functional domains demonstrates the magnitude of English influence and depth of penetration in Chinese society. It is argued that nativization of English in China forms a CLINE, for the degrees of nativization in terms of English as a medium of …
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Model-based Deployment Optimization of Automotive Multi- and Many-Core Systems
… typically consisting of about 100 mainly mono-functional electronic control units are driven towards centralized electrical/electronic architectures to handle the computational demands. Accordingly, the process of integrating software is becoming increasingly challenging, as a mixture of …
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Comparative Biochemistry of Drug-Binding Proteins in Calmodulin/S100 Family
… is a member of a class of structurally and functionally related proteins. Calmodulin is widely distributed among eukaryotes, and the amino acid sequence of calmodulin is highly conserved. The protein contains multiple structural domains and has multiple activities in vitro, including calcium …
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Structure and Function of the Yeast Chromosomal Replicator Ars1 (Plasmid)
… Saccharomyces cerevisiae. In order to define the functional domains of ARS1 and determine its role in plasmid maintenance, I have performed in vitro mutagenesis in the region containing ARS1 and measured their effects on Ars activity using the parameters of high-frequency transformation, colony …
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Requirements for Compartmentalization of Penicillin-Binding Proteins during Sporulation in Bacillus subtilis
… classes based upon their molecular weights and functional domains. Gene expression is regulated in the two differentiated cells in Bacillus subtilis, the mother cell and the forespore, by coordinated expression of different sigma factors that recognize specific promoters in each compartment. The …
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Characterization of C-Gmp Dependent Kinases Within the Circadian Molecular Clockworks: Structural, Phylogenetic, and Functional Analyses
… family. Homology based structural models of the functional domains of the cGK family indicate impressive conservation within the cyclic nucleotide binding domains and within the catalytic loop and activation segment as well as the substrate binding cleft. We propose that cGK family members vary …
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Parietal dysfunction in children with prenatal alcohol exposure
… most affected by prenatal alcohol exposure. Functional domains dependent on intact parietal functioning, including mathematical and visuospatial ability, have been consistently implicated in fetal alcohol spectrum disorders. This thesis examines, in children, using blood oxygenation level …
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Predictors of Neuropsychological Status in Cardiac Patients
… status of heart patients across several functional domains, while affective factors (depression, anxiety, stress) were less predictive. For Aim 2, cognitive variables were not significantly associated with whether or not a patient adheres to cardiac rehabilitation. Results indicate that …
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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing
… out and amino acid changes occurring outside of functional domains were identified within the nucleocapsid and glycoprotein. I observed several amino acid changes in functional domains of the RNA-dependent RNA polymerase, as well as single nucleotide polymorphisms (SNPs) within the 3’ non-coding …
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