Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"functional discovery"”.
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Functional discovery and promiscuity in the RuBisCO superfamily
… with misannotated sequences, a new method of functional annotation is necessary. The new method is called “genomic enzymology” and utilizes bioinformatics, molecular docking, microbiology, and enzymology. For a superfamily to benefit from this new strategy there must exist a set of solved …
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Functional discovery in the oxidative D-galacturonate assimilation pathway and development of the enzyme similarity web tool
… metabolizing D-galA. This work lead us to the discovery of an enzyme that hydrolyzed the 6-member ring lactone of D-galA to its acyclic diacid counterpart, meso-galactarate.
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Structurally Motivated Deep Learning for Genome Scale Protein Interaction Prediction
… tool in systems biology to facilitate the discovery and understanding of protein function. However, experimental PPI data remains sparse in most model organisms and even more so in other species. Existing methods for computational prediction of PPIs seek to address this limitation, and …
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Functional metagenomic discovery and characterisation of CAZymes by microfluidic methods
… exhibit the required properties. Therefore, the discovery and thorough characterisation of new biocatalysts is imperative to smoothen the path for a greener future. With the emergence of large-scale metagenomic sequencing projects, the number of protein sequences in databases has grown …
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Functional and physiological discovery in the mannonate dehydratase subgroup of the enolase superfamily
… databases. This dissertation details the functional and physiological characterization of the mannonate dehydratase subgroup (ManD) of the enolase superfamily (ENS). The outcome affirms the dangers of homology-based annotations while discovering novel metabolic pathways. Furthermore, the …