Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"functional cure"”.
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Characterising the immunopeptidome in hepatitis B
… carcinoma (HCC) worldwide. There is presently no cure for HBV, and treatment options aim to reduce the risk of liver related complications and HCC. Immunotherapies have not been successful in achieving the long-term immune control required for functional cure. The display of HBV-derived peptides …
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To Stop or Not to Stop: Response After Nucleos(t)ide Analogue Withdrawal Among Patients With Chronic Hepatitis B
… hepatitis B surface antigen (HBsAg) loss, or “functional cure” is rare on therapy. NA withdrawal results in higher rates of HBsAg loss but remains controversial because of the possibility of HBV flares. This thesis aims to investigate long-term outcomes after NA cessation and determine …
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DESIGN, SYNTHESIS, AND OPTIMIZATION OF SMALL-MOLECULE CD4 MIMETICS AS HIV-1 ENTRY INHIBITORS AND SYNTHETIC EFFORTS TOWARD THE TOTAL SYNTHESIS OF NAHUOIC ACID Cii
… with significant implications for future functional cure strategies. Part II: The Nahuoic acids are polyhydroxylated polyketides defined by a cis-decalin core fused to a highly oxygenated polyol side chain. First isolated from marine Streptomyces strains, these metabolites attracted …
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Mathematical and Numerical Investigation of Immune System Development and Function
… hepatitis B s antigen clearance, defined as the functional cure point of chronic hepatitis B infections. Drug therapy clinical trials that combined RNA interference drug ARC-520 with entecavir have shown promising results in reducing hepatitis B s antigen titers. We develop …