Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"functional compensation"”.
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The Role of Cdx in Intestinal Development
… are viable and fertile, to examine potential functional compensation between these family members. The major findings of this study are that Cdx2 regulates patterning and differentiation of the small intestinal epithelium, while Cdx1 does not appear to make a contribution to either process. …
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Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
Structural and functional plasticity induced by neuronal competition is a common feature of developing nervous systems. However, the rules governing how postsynaptic cells differentiate between presynaptic inputs are unclear. In this thesis, I characterized synaptic interactions following …
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CROSSTALK BETWEEN PRC1 AND PRC2 IN INTESTINAL LINEAGE COMMITMENT AND CELL IDENTITY
… stages of development to adulthood. How they functionally preserve transcriptional silencing has been deeply explored in embryonic stem cells (ESC), but remains poorly described in an in vivo context. Taking advantage of Cre-dependent conditional knockout mouse models targeting distinct …
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High-Definition Fiber Tracking Study of the Executive Control Network in Blast-Related Traumatic Brain Injury
… The current study evaluated structure and functional correlates of executive control network (ECN) white matter tracts in veterans with and without bTBI to investigate the clinical utility of using High Definition Fiber Tracking (HDFT) to identify a biomarker of chronic bTBI. For the …
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The Neural Correlates of the Age-Related Decrements in Selective Attention That Occur in Healthy Cognitive Aging: an FMRI Study of the Stroop Task
… of the classic Stroop Task, concurrently with functional MRI scans. We recruited 60 cognitively normal participants from 40-90 years of age, with 12 participants within each decade group. We found that the bilateral Middle Frontal Gyrus (MFG) was the only area to exhibit unanimous, linear …
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Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention
… confound cognitive testing due to contralateral functional compensation. Thus, the aim of this thesis was to use an AAV2/6 viral vector overexpressing human wild-type α-synuclein to characterise NMS of PD, exploring behavioural phenotypes of both unilaterally- and bilaterally-administered …
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Functional Analysis of Plant Glutamate Receptors
… GLRs likewise require different subunits to form functional channels. A modified yeast-2-hybrid system approach was initially taken and applied to 14 of the 20 AtGLRs to identify a number of candidate interactors in yeast. Forster resonance energy transfer (FRET), which measures the transfer of …
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The function of golgin vesicle tethers in Drosophila melanogaster
… Furthermore, Golgin-97 and Golgin-245 exhibited functional differences in Drosophila tissues despite reported functional redundancy in mammalian tissue culture cells (Shin et al., 2017). This finding led to the generation and study of Drosophila knock-out and knock-in lines of Golgin-97/245 …
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The Neurotrophic Influence on Craniofacial Development Subsequent to in Utero Unilateral Transection of the Trigeminal(V) Nerve
… inherent (i.e., genetic) and independent of both functional demand and biomechanical factors. Normal growth and maturation of the skeletal components were achieved without neural innervation; however, maintenance of the functional skeletal form, of the proliferating progenitor cells of the …