Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"functional classes"”.
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Computational investigation of membrane proteins across species and functional classes
… membrane-associated proteins across species and functional classes, spanning both peripheral and integral membrane proteins. I characterize the membrane-binding mechanism of human beta-2-glycoprotein I, revealing key electrostatic and hydrophobic interactions that drive anionic lipid recognition …
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Design, Synthesis, and Applications of Chiral Stationary Phases
… enantiomers of solutes from a wide range of functional classes.
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Quantifying the Impact of Pavement Surface Properties on Road Safety: A Data-Driven Approach
… can affect a model's crash prediction across HSM Functional classifications. A network level dataset of 0.1-mile roadway segments was assembled across selected HSM functional classes, N = 12,474; 14 classes, linking reported crashes to exposure (lnAADT), roadway geometry, and pavement surface …
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Combinatorial gene regulation by transcription factors
… patterns that separates TFs into potential functional classes. Together, our results suggest a structure of the regulatory code at the level of TF function and generate new hypotheses about regiospecific binding patterns and functions of TF classes within enhancers.
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A theory for national industrial development presented in a system dynamics model
… by ten activity sectors grouped into three functional classes: (1) Two driving sectors comprising population and investment capital sectors; (2) Seven industrial sectors: resources, manufacturing, agriculture, physical infrastructure, services, technology, and social infrastructure; and (3) …
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Evolutionary signatures for unearthing functional elements in the human transcriptome
… genomics is a powerful method for identifying functional genetic elements by their evolutionary patterns across species. However, current studies largely focus on analysis of genome sequences. The recent development of RNA-sequencing reveals dimensions of regulatory information previously …
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
… indicated induction of genes in three major functional classes - xenobiotic detoxification, sarcomere structure, and energy transfer. TCDD-modulation of selected genes was verified by RT-PCR. Induction of mitochondrial electron transfer genes was variable and modest; such induction provides a …
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Integrating Novel Connected Vehicle Event Data for Proactive Road Safety Improvement
… crashes and HBE across different roadway functional classes and urbanized and rural areas in Alabama. The correlation was conducted at the segment level to provide a preliminary insight into the classes of roadways where HBE could be most appropriate as surrogates of historical crashes. …
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The effect of overfeeding and obesity on canine adipose tissue and skeletal muscle transcriptomes
… differentially expressed genes and enriched functional pathways between subcutaneous and gonadal adipose of lean and obese dogs at 24 wk of the animal experiment described in study 1. Subcutaneous adipocytes of obese dogs were larger than obese gonadal and lean subcutaneous and gonadal …
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Characterisation of novel and complex mechanisms of antobiotic resistance using a proteomics approach
… of many proteins, spanning a broad range of functional classes, including the MinCDE cell division inhibitors, iron acquisition proteins such as FepA and FhuA and proteins involved in biofilm and LPS formation such as PapC, LptD and GmhA. Overall this project has highlighted the complex and …
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Function and evolution of seminal fluid components in Drosophila
… Despite this rapid turnover, conservation of functional classes is frequently seen, suggesting evolutionary constraint on fundamental reproductive processes. One such functional class of SFPs is the family of odorant binding proteins (Obps), which are common members of the arthropod ejaculate. …
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Molecular Mechanisms of HIV-1 Infection: Viral and Host Determinants in Transmission and Pathogenesis
… viral heterogeneity and a high conservation of functional domains for biological activity and CTL response. With respect to differential mechanisms of HIV-1 infection in neonatal vs. adults cells, 468 HIV-1 integration sites were characterized in the T-lymphocytes and …
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The Molecular Correlates of Sleep and Sleep Deprivation in vivo and in vitro
… the unfolded protein response. Although these functional classes are reminiscent of those modulated by in vivo sleep deprivation, there was only a slight enrichment of individual genes modulated by in vivo sleep deprivation amongst the blue light sensitive genes, indicating further work is …
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The role of common stimulus functions in the development of equivalence classes.
… eight participants, three 3-member contingency classes resulted. When the same stimuli were presented in a match-to-sample procedure under test conditions, four participants demonstrated equivalence-consistent responding, matching all stimuli from the same contingency class. Test performance for …
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Natural selection on MRNA secondary structure and its correlation with protein functional groups
… The distributions of MFEs of mRNAs of 25 broad functional classes of proteins (COGs - Clusters of Orthologous Groups) of five microbes and yeast correlate to functional class. mRNA prefixes have a distinctive MFE signature. The naturally occurring prefixes display more structure, on average, …
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Do Shared S-minus Functions Among Stimuli Lead to Equivalence?
We examined the claim that equivalence classes contain all positive elements in a reinforcement contingency by asking whether negative stimuli in a reinforcement contingency will also form an equivalence class, based on their shared function as S-minus stimuli. In Experiment 1, 5 subjects were …
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Targeting Psychological Flexibility in Youth to Enhance Health-Related Behaviors
… Frame Theory, and Evolution Science to target functional classes of behavior and facilitate health-promoting behaviors in youth. Purpose: The present study is a preliminary investigation examining the feasibility, acceptability, efficacy, participant characteristics (e.g., trait mindfulness), …
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A mouse model to study inducible oncogene cooperation <i>in vivo</i>
… nd/orl oss of tumour suppressors from different functional classes is necessary for transformation to proceed.<br></br><br></br> In fact, it was observed that, although overexpression of a single oncogene does not transform wild-type mouse embryonic fibroblasts, combinations of <i>myc</i> and …
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Application of Different Bioanalytical Workflows for Proteomics of Prostate Cancer
… spots were identified and grouped into various functional classes. The major protein categories were metabolism (52%), stress response (12%), protein biosynthesis (13%) and apoptosis (11%), suggesting that alterations in these processes may be involved in the mechanism of drug action. Proteins …
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Transcriptomic analyses of Clostridium beijerinckii NCIMB 8052 during transition from acidogenesis to solventogenesis and under butyrate supplemented conditions
… profiling are essential for understanding the functional and regulatory network of the genome and specific gene functions and regulations associated with the cell physiology, the physical structure of the transcriptome and the transcriptional profiles were not well understood for C. …