Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 273 for “"functional characterization"”.
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Functional Characterization of CRIP1a Knockout Mice
CB1 cannabinoid receptors are G-protein-coupled receptors that mediate the central nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits …
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Functional characterization of mobilized tumor cells
… pleural effusions (MPE). We investigated the functional behavior of mobilized tumor cells in order to explain the discrepancy between the number of tumor cells in circulation and the number overt metastases. The first part of this thesis examines the functional behavior of CTCs isolated from …
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Functional Characterization of Amphiphysin in Drosophila melanogaster
… approach to ask if different Amph functional domains could rescue the t-tubule and locomotory defects observed in amph mutants. Partial rescue was observed for most constructs, suggesting that Amph function was dependent on more than one domain. To further elucidate how Amph …
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Functional characterization of human and chicken TLR3
… TLR3 (chTLR3) have been identified, but their functional significance remains unexplored. This thesis sets the foundation for investigating the impact of chTLR3 polymorphisms on receptor activity and downstream signaling. Using an NF-κB-driven GFP reporter cell line that lacks endogenous TLR3, …
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Functional characterization of nitrate transporters in maize.
… expression in either root or shoot tissues. Functional characterization studies were conducted on ZmNPF6.4 and ZmNPF6.6 as there was no nitrate transport activity measured with ZmNPF6.5 and ZmNPF7.10 using a preliminary screening experiment in Xenopus laevis oocytes. Combining …
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Functional Characterization of the Streptococcus sanguinis com Regulon
Streptococcus sanguinis is an important component of the dental plaque biofilm and is believed to play a beneficial role in the oral cavity. S. sanguinis is also a leading cause of infective endocarditis (IE), a potentially lethal infection of the cardiac valves. S. sanguinis possesses genetic …
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The functional characterization of a novel protein, Liat1
… pathway of protein degradation. However, its functional significance remains unknown. This study is the first functional characterization of Liat1. Here, we found that the N-terminal half of Liat1 is intrinsically disordered. Intrinsically disordered proteins tend to drive a phenomenon called …
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Functional characterization of the RNA binding protein RALY
… protein into the cell and I characterized the functional nuclear localization sequence that localizes RALY protein into the nuclear compartment. In order to better understand the role of RALY in the cells, I identified the proteins component of RALY-containing complexes using a new assay named …
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Functional Characterization of Metallothioneins in Arabidopsis and Barley
<p>Metalothioneins (MTs) are metal binding proteins that can bind metals such as Cu, Zn, and Cd but the functions of MTs in plants are largely unknown. To understand the function of MTs in Arabidopsis, T-DNA insertion mutants lacking 4 MT genes including <em>MT1a, MT2a, MT2b</em> and <em>MT3</em> …
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Structural and functional characterization of signaling protein complexes
The Ras/ERK pathway is a ubiquitous kinase cascade, so regulation of this pathway is critically improtant. Examples from two regulatory proteins, c-Cbl and calmodulin are presented. c-Cbl is an E3 ubiquitin ligase and a major regulator of tyrosine kinases. Through x-ray crystallography of five …
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FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
Denn stands for differentially expressed in normal vs neoplastic cells, Dennd5a or Denn domain containing protein 5a is also named Rab6 interacting protein 1 (Rab6ip1), KIAA1091 (HUGE database). Rab6 is a small GTP-binding protein that involves in intra-Golgi transport. In a yeast two hybrid screen …
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Functional characterization of Phosphodiesterase-4A in behavior and obesity
… factors from immune cells; however, the functional role that PDE4A plays in behavior was not known. The purpose of this dissertation was to characterize the functional role of PDE4A in behavior through the use of PDE4A KO mice, and a battery of behavioral and biochemical tests. We found …
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Functional Characterization of a Cathepsin L in Drosophila Melanogaster
<p>The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that invasively grows toward and into the wing imaginal disc. The unfolding of Drosophila wing is a process following eclosion with a cuticular bilayer replacing epithelial cells originally packing the wing. We reasoned that …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
The human immunodeficiency virus (HIV) infects over 39.5 million people worldwide (UNAIDS/WHO 2006 Epidemic Report). Unfortunately, various socioeconomic factors have hastened the epidemic spread of HIV in Africa and in third world countries where many individuals do not have access to appropriate …
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Substrate specificity and functional characterization of sodium/dicarboxylate cotransporters
… mouse (m) and rabbit (rb) NaDC1, and functional characterization of a high-affinity NaDC transporter from Xenopus laevis, xNaDC3. \r\n\r\nAlthough sharing strong sequence identity, mNaDC1 and rbNaDC1 differ in their ability to transport certain dicarboxylates. For example, oocytes …
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Functional Characterization of Atxa, The Bacillus Anthracis Virulence Regulator
<p>Coordinated expression of virulence genes in <em>Bacillus anthracis</em> occurs via a multi-faceted signal transduction pathway that is dependent upon the AtxA protein. Intricate control of <em>atxA</em> gene transcription and AtxA protein function have become apparent from studies of …
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Functional Characterization of Neurexophilins in the Central Nervous system
In der vorliegenden Arbeit wurde die Lokalisation und Funktion von Neurexophilinen mittels eines neurogenetischen Ansatzes im Gehirn von Mäusen untersucht. Neurexophiline (Nphs) konstituieren eine Proteinfamilie von Glykoproteinen, die ursprünglich als eine Komponente der alpha-Neurexine isoliert …
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