Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"functional annotation analysis"”.
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
… genes [log2(fold change)>2] were identified. Functional annotation analysis and literature research were used to select genes for the targeted CRISPR screen, which highlighted the importance of HIF-1$\alpha$ and NFIL3 in CTL killing. The second half of the thesis focuses on primary human CTL. …
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Proteomics studies of protein homeostasis and aggregation in ageing and neurodegeneration
… and differ only in the degree of binding. Functional annotation analysis on the groups reveals a preference of the oligomers to bind proteins in specific biological pathways and categories, including in particular mitochondrial membrane proteins, RNA-binding proteins and molecular …
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An investigation of the role of CreB deubiquitinating enzyme in the regulation of carbon metabolism in Aspergillus nidulans
… genetic interaction, and this was extended to analysis of complete loss-of-function alleles. Both morphological and phenotypic analyses of the double null mutant confirmed genetic interactions between the genes. Moreover, RT-qPCR and enzyme assays also validated genetic interactions as the …
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Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
… cerevisiae. It exists in two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1), and mTOR complex 2 (mTORC2). mTORC1, a rapamycin sensitive protein complex, senses the availability of growth factors, nutrients, cellular energy levels, and is actively involved in cellular …