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Showing 1 to 5 of 5 for “"functional amyloids"”.
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Application of Functional Amyloids in Morphological Control and in Self-assembled Composites
Amyloids are self-assembled protein materials containing beta-sheets. While most studies focus on amyloids as the pathogen in neurodegenerative disease, there are instances of "functional" amyloids used to preserve life. Functional amyloids serve as an inspiration in materials design. In this …
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Kinetics of Peptide Aggregation
… mechanism to protect or destroy life. Pathogenic amyloids are the signature of neurological disorders such as Alzheimer's and Parkinson's disease and bovine spongiform encephalopathy (BSE), which have no effective treatments or known cures. Pathogenic amyloids appear as nanometer sized "plaques" …
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Self-Assembly of Large Amyloid Fibers
Functional amyloids found throughout nature have demonstrated that amyloid fibers are potential industrial biomaterials. This work introduces a new 'template plus adder' cooperative mechanism for the spontaneous self-assembly of micrometer sized amyloid fibers. A short hydrophobic template peptide …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… BapA, and extracellular DNA. Curli are functional amyloids with a rich β-sheet structure strikingly similar to pathological and immunomodulatory human amyloids such as β-amyloid, α-synuclein, and serum amyloid A. It is often debated if enteric bacteria express curli and form biofilms in …
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Rational Design and Scalable Production of De novo Autogenic Engineered Living Materials
Rational Design and Scalable Production of De novo Autogenic Engineered Living Materials Hoda Mohsen Youssef Hammad General Audience Abstract This work introduces a new approach to creating "engineered living materials" that combine biology with advanced protein engineering to form dynamic, …