Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"fumarase"”.
-
A New Substrate for Fumarase, L-Trans-2,3-Epoxysuccinate
Made available in DSpace on 2014-12-10T23:00:57Z (GMT). No. of bitstreams: 1 7114657.pdf: 3710536 bytes, checksum: 0173d0666dedba50de3735166a1395f7 (MD5) Previous issue date: 1970
-
Inhibition of enzymes from mycobacteria using fragment-based approaches
… target proteins, fumarate hydratase (fumarase) from Mycobacterium tuberculosis (Mtb) and tRNA (m1G37) methyltransferase (TrmD) from Mycobacterium abscessus (Mab). With Mtb fumarase a high-throughput screening (HTS) hit was used to design a small library of fragments in a …
-
"Isozyme variation in ""helminthosporium-type"" species pathogenic on maize"
… with aspartate aminotransferase (EC 2.6.1.1), fumarase (EC 4.2.1.2), glucose-6-phosphate dehydrogenase (EC 1.1.1.49), and mannose-6-phosphate isomerase (EC 5.3.1.8). Associated electrophoretic and virulence phenotypes were found, indicating that populations exist in S. turcica as asexually …
-
The metabolism of iron-sulfur clusters during hydrogen peroxide stress in escherichia coli
… clusters in isopropylmalate isomerase but not in fumarase. The reason was that damaged [3Fe-4S] clusters in IPMI were degraded in vivo, possibly to an apoprotein form, and thus required de novo assembly system for reactivation. In contrast, the [3Fe-4S] clusters in fumarase were stable and could …
-
Oxidative stress in anoxic habitats
… of B. thetaiotaomicron. Two of these enzymes, fumarase and pyruvate formate lyse (PFL), were reported to be damaged by O2- and molecular O2 respectively. In this study, we show that the third enzyme, pyruvate ferredoxin oxidoreductase (PFOR), is also damaged by molecular O2 itself. Pyruvate …
-
Biostabilization of Lipid Bilayers: Dealing with Water Stress in Embryos of Artemia franciscana
… occurred simultaneously with the release of fumarase, a matrix-resident marker. As a second independent method to corroborate the above findings, I demonstrated that recombinant AfrLEA3m can be imported into mitochondria isolated from rat liver. Molecular modeling of AfrLEA2 and AfrLEA3m …
-
Secondary problems caused by the oxyr response to hydrogen peroxide stress in Escherichia coli
… activities not only of the iron-dependent enzyme fumarase A but also of the iron-independent enzyme isocitrate dehydrogenase. These cells are also unable to transition smoothly out of prolonged stationary phase. Single-gene deletions of various members of the OxyR regulon did not identify the gene …
-
Development of imaging techniques to assess tumour cell death
… hydrated in the reaction catalysed by the enzyme fumarase to produce malate. With loss of plasma membrane integrity in dying cells fumarate can rapidly gain access to the enzyme. By measuring increased malate production in treated tumours after fumarate injection, cell necrosis can be assessed. It …
-
Genetic basis of inherited kidney and related tumours
… RCC risks were calculated for participants with fumarase deficiency (FMRD) related variants (4%; 95%CI:0.88-1 by age 75 years). Overall frequency of candidate P/LP *FH* variants in the 100KGP cohort was 1 in 200; 1 in 5,000 for HLRCC-related variants and 1 in 250 for FMRD related *FH* variants …