Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"fucosylation"”.
-
Studies on fucosylation in Trypanosoma brucei
The biosynthesis of GDP-Fucose, the activated donor for fucose, has been recently shown to be essential in the parasite Trypanosoma brucei. Fucose is a common sugar modification on eukaryotic glycan structures, but it has not been well described in trypanosomatids. To elucidate the role of fucose …
-
Discovery of Glyco-biomarkers for Diabetes and Complications in Diabetes
… with statistical significance. The elevated fucosylation in diabetes was verified at the glycosylation site level by quantitative Aleuria aurantia lectin (AAL) pull-down experiments. Fucosylated fetuin-A and α-1-acid glycoprotein were selected as candidate glyco-biomarkers. A lectin ELISA …
-
The Development of Novel Tools for the Metabolic Labelling of Glycans in Cancer
… is studied, targeting the well-known enhanced fucosylation in cancer.
-
PROTEIN PURIFICATION FROM GASTROPODS
… pattern with a focus on their sialylation and fucosylation abilities. Their sialylation potential was investigated by Sambucus nigra agglutinin and Maackia amurensis agglutinin while their fucosylation potential was investigated by Aleuria aurantia lectin, Lens culinaris agglutin, Lotus …
-
Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… increased fucose levels may be due to abnormal fucosylation of plasma or intestinal mucosal proteins involved in leukocyte trafficking. Comparisons of the urinary metabolite profiles of IL10-/- and wildtype mice also revealed eleven metabolite differences that were unaffected by inflammation …
-
Analysis and characterisation of human chorionic gonadotropin glycoforms in pregnancy and trophoblastic disorders
… contained a combination of multiple branching, fucosylation, sialylation, sulphation and glycans with Lewis X terminal epitopes. In summary, we have successfully developed a methodology for the detection of a diverse range of N-linked glycans from hCG. These results suggest that this approach …
-
Harnessing N-glycans as Next Generation Prebiotics
… exclusively complex, or core alpha 1,3 fucosylation. All three enzymes were exclusively active on oligomannose but could not remove complex or alpha 1,3 fucosylated N- glycans. Together, these experiments demonstrate how subtle differences in N-glycan composition impact the gut …
-
N-Glycosylation profiles as a risk stratification biomarker for Type II Diabetes Mellitus and its associated factors
… (S0), monogalactosylation (G1), core fucosylation (FUC_C), biantennary galactosylation (A2G) and biantennary (BA) Nglycans were decreased compared to controls (Study III). Biguanides alone, or in combination with sulfonylurea and thiazolidinedione, did not improve glycaemic status at …
-
REGULATION OF GLYCOSYLATION IN MAMMALIAN CELL LINES: INSIGHTS FROM STRUCTURAL GLYCOMICS, ANALYSIS OF GLYCOSYLATION-RELATED GENES AND FUNCTIONAL RNAI SCREENS
… glycans to complex-type glycans as well as in fucosylation of glycans. On this basis, it is tempting to speculate that multiple kinases and phosphotases can regulate the glycosylation process upstream of the glycosylation pathway in response to extracellular or intracellular signals. In …
-
Ein Knockout-Mausmodell für Congenital Disorder of Glycosylation-IIc: Defizienz des Golgi-GDP-Fucose-Transporters
Die monogenetisch vererbten humanen Erkrankungen der 'Congenital Disorders of Glycosylation' (CDG) werden durch Defekte von Enzymen und Transportern verursacht, die an der Modifikation von Proteinen durch kovalente Verknüpfung mit verschiedenen Zuckerbausteinen beteiligt sind. Die große Bedeutung …