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Showing 1 to 4 of 4 for “"free energies of binding"”.
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Binding affinity of a small molecule to an amorphous polymer in a solvent
… on a foreign surface. The complicated mechanism of heterogeneous nucleation is not well understood, but we hypothesize a possible correlation between binding affinity to a surface and nucleation enhancement. Amorphous polymers have been used in controlling crystallization. However, to our …
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The Atom Surface Site Interaction Point Approach to Non-Covalent Interactions
… equations that describe the electronic structure of the atoms but also informed us that such accurate calculations are very expensive indeed. To look at larger supramolecular or biomolecular systems, or to investigate the effects of solvent, simplifications needed to be introduced that compromise …
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Probing the Role of Nascent Helicity in Protein Function: p27kip1 as a Regulator of the Cell Cycle
… binds to and regulates the activity of cyclin-dependent kinases (Cdks) which are the master timekeepers of the cell division cycle. Members of the p27 family of proteins, also including p21 and p57, are called cyclin-dependent kinase inhibitors (CKIs). The amino terminal domain of p27 …
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Evolution and dynamic behavior of transfer RNA in the first two steps of translation
In protein synthesis, a key component of the cellular machinery is transfer RNA (tRNA). This small nucleic acid is crucial to the maintenance of the genetic code because it discriminately binds the messenger RNA codon at the ribosome and adds the cognate amino acid to the growing polypeptide chain. …