Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"fragment-based ligand design"”.
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Targeting del sistema enzimatico dell'eme ossigenasi come nuovo approccio nella terapia antitumorale
La complessità intrinseca dei meccanismi molecolari coinvolti nell’insorgenza del tumore rappresenta uno dei principali problemi che contribuisce al fallimento delle comuni terapie antineoplastiche. Gli attuali regimi terapeutici si basano sull'applicazione di diversi protocolli volti a rallentare …
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Fragment-based approaches to targeting EthR from mycobacterium tuberculosis
… elaboration of three chemical scaffolds using fragment-based approaches to develop novel inhibitors capable of disrupting the EthR-DNA interaction. The first scaffold, 5-(furan-2-yl)isoxazole was investigated by fragment-merging approaches and produced compounds with the best of these having a …