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Showing 1 to 1 of 1 for “"fragment-based GPCR discovery"”.
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Bioorthogonal Tethering of Drug Fragments to Engineered G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) modulate diverse cellular signaling pathways and are important drug targets. Despite the availability of high-resolution structures for nearly 100 discrete GPCRs in complex with various ligands, discovering allosteric drugs that can modulate receptor signaling …