Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 1 of 1 for “"fragment based lead discovery"”.
-
Structure-Based Drug Design Against a Biosecurity Pathogen
… substrate bound structure. X-ray crystallography-based fragment screening is then applied, identifying a large number of binding fragments, bound not only to the active site but also an allosteric site. We show that binders inhibit enzyme activity, with promise for further development. Lastly, …