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Showing 1 to 20 of 52 for “"fragilis"”.
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DNA repair in bacteroides fragilis
Bacteroides fragilis is a gut commensal in both humans and animals where it benefits the host through metabolizing indigestible compounds, stimulating the immune system and protecting against pathogen colonization. However, it is also an opportunistic pathogen, responsible for approximately half of …
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Glutamine synthetase in Bacteroides fragilis
Bactereroides fragilis is a gram-negative, non spore-forming, obligate anaerobe of the human intestinal microbiota. It is, however, an opportunistic pathogen and has been ranked as the most prevalent isolate in cases of anaerobic septicaemia. Similar to most bacteria, ammonium is assimilated in B. …
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Molecular genetic studies of bacteroides fragilis
Some genetic systems operative in Bacteroides fragilis have been successfully investigated. Firstly the bacteriocin produced by the B.fragilis BF-1 strain was purified and partially characterized. This bacteriocin was found to be cell bound and constitutively produced by the bacteria. The purified …
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Characterization of TraM, a Required Bacteroides Fragilis Conjugal Apparatus Protein That Interacts with the B. Fragilis Putative Coupling Protein Bcta and the B. Fragilis Relaxase Protein BmpH
… from the genus via conjugation. The <italic>B. fragilis</italic> clinical isolate LV23 harbors a 37kb conjugative transposon, BTF-37. Two important conjugal apparatus proteins encoded by BTF-37 are BctA, a predicted coupling protein (CP) that powers DNA translocation, and ORF7 (TraM). In this …
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DNA repair in Bacteroides fragilis Bf-2
Repair deficient mutants of Bacteroides fragilis have been isolated in order to study the responses of this organism to various DNA damaging agents at the physiological and molecular levels. Two types of mutants were isolated by ethyl methane sulphonate mutagenesis of B.fragilis followed by …
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The effect of metronidazole on Bacteroides fragilis and Escherichia coli
… caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the …
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Characterization and Molecular Analysis of Fragilysin: The Bacteroides fragilis Toxin
Bacteroides fragilis is a gram negative, anaerobic rod, that is a member of the normal colonic microflora of most mammals, and it is the anaerobe most commonly isolated from human soft tissue infections. During the past decade, strains of B. fragilis that produce an enterotoxin have been implicated …
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Cloning and expression of cambialistic Bacteroides fragilis superoxide dismutase gene
… a LambdaGEM-11 genomic library of <i>Bacteroides fragilis</i>. In order to generate a complete genomic library, <i>B. fragilis</i> genomic DNA was partially digested with the restriction endonuclease Sau3AI and was ligated to cloning vector, LambdaGEM-11. After in vitro packaging, DNA was used to …
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The Induced Synthesis and Properties of Beta-Galactosidase of Saccharomyces Fragilis
Made available in DSpace on 2014-12-05T21:45:28Z (GMT). No. of bitstreams: 1 0020863.pdf: 4404780 bytes, checksum: ede4ac7bc409c2f111529040f819bf08 (MD5) Previous issue date: 1957
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Role and regulation of glutamate dehydrogenase activity in Bacteroides fragilis bf1
Bacteroides fragilis is a gram-negative obligate anaerobe that exists normally in the human large intestine. It is, however, capable of causing a variety of infections once outside of this environment. Previous studies have suggested that the regulation of the ammonia assimilatory pathways in B. …
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Crystal structure of the Large Type III Glutamine Synthetase from Bacteroides Fragilis
… the opportunistic human pathogen, Bacteroides fragilis, with a view to better understanding the GSIII family in the light of the known structure functionrelationships of the other GS enzymes, and to investigate the potential for the design of selective inhibitors against the divergent family. A …
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The molecular characterisation of the recA locus in the opportunistic pathogen Bacteroides fragilis
Bacteroides fragilis is a human gut commensal and an opportunistic pathogen causing anaerobic abscesses and bacteraemias which are treated with the drug, metronidazole, a DNA damaging agent. The RecA protein is thought to be involved in the repair of metronidazole damage as well as damage caused by …
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Serological and chemical studies on the antigens of Bacteroides Fragilis and related species
… antigens extracted from strains of Bacteroides fragilis and related species belonging to several different DNA homology groups were investigated. Antisera prepared against formalin-treated whole cells suspensions of representative strains were tested against cell suspensions, cell wall …
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Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix
Bacteroides fragilis is an opportunistic pathogen which can cause life threatening infections in humans and animals. The increasing incidence of antibiotic resistance by the bacterium has prompted the search for novel therapeutic targets. The idea of antivirulence over antimicrobial drug …
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HISTOLOGICAL AND GEOCHEMICAL PROPERTIES OF PATHOLOGICAL VERSUS NORMAL BONE IN ALLOSAURUS FRAGILIS AND MODERN AVIANS
… phalanges from the theropod dinosaur Allosaurus fragilis, and two modern bird species, Branta canadensis (Canada goose) and Cathartes aura (turkey vulture). Raman spectroscopy analysis was performed on modern birds, but not fossil material. Stable isotope and rare earth elements (REE) analyses …
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Metronidazole resistance in clinical Bacteroides fragilis isolates from Groote Schuur Hospital, Cape Town, South Africa
Bacteroides fragilis, an anaerobic gut commensal and opportunistic pathogen, is a leading cause of anaerobic abscesses and bacteraemias. Treatment of infections is complicated by the emergence of resistance to several of the antibiotics, specifically metronidazole, used in the clinical setting. The …
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Effects of far ultra-violet radiation and oxygen on macromolecular synthesis and protein induction in Bacteroides fragilis Bf-2
… viability in the obligate anaerobe, Bacteroides fragilis, as well as the specific proteins induced in this organism by these different DNA damaging agents.
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Anaerobic Digester Liquor as a Source of Ammonium and Phosphate For Single-Cell Protein Production
… of the yeasts Candida utilis and Kluyveromyces fragilis. It was found that a pH of 4.0 and a temperature of 30°C yielded optimum growth. The optimum carbohydrate concentration differed with the organism and the sugars tested. The uptake of the inorganic nutrients, phosphate and ammonia, was …
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Identification of Bacteroides genes involved in Metronidazole resistance
… Certain Bacteroides species, such as B. fragilis and to a lesser extent B. thetaiotaomicron, can become opportunistic pathogens and cause severe infection. The antibiotic of choice for treating such infections is metronidazole, a DNA damaging agent. Metronidazole enters the bacterial cell …
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