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Showing 1 to 4 of 4 for “"fosfazinomycin"”.
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Investigating the biosynthesis of fosfazinomycin
… transformations. One example comes from fosfazinomycin, an antifungal compound bearing a unique phosphonohydrazide (C-P-N-N-C) linkage that joins a valine-arginine dipeptide to methyl-2-hydroxyphosphonoacetate (Me-HPnA). This thesis describes my efforts towards determining how the …
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Flavin-dependent Enzymes in Natural Product Biosynthesis
… heteroatom oxidation as part of allicin or fosfazinomycin biosynthesis respectively. AsFMO was predicted to oxidize S-allyl-L-cysteine (SAC) to alliin in allicin biosynthesis. Surprisingly, AsFMO exhibited negligible activity with SAC, and instead was highly active with allyl mercaptan and …
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… the biosynthetic pathways of dehydrophos, fosfazinomycin, and rhizocticin (chapter 5).
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Oxygen-dependent enzymes involved in phosphonate biosynthesis
… a compound with proven antibiotic activity, fosfazinomycin, a compound containing a unique phosphono-hydrazide linkage, and hydroxyphosphonocystoximate, a phosphonate containing an unusual thiohydroximate moiety. Here, I show that these enzymes share little identity with one another, which …