Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"formulation design"”.
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Accelerating Liquid Formulation Design using Lab Automation and Machine Learning
Liquid formulations are ubiquitous yet have lengthy product development cycles owing to the complex physical interactions between ingredients, making it challenging to tune formulations to customer-defined property targets. Methods to accelerate liquid formulation design are desired to address …
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Microfluidics technology for the formulation design and production of liposomal products
… is a lack of defined operating parameters and designed space for liposome production. To this end, this thesis focuses on microfluidics technology for the production of a range of liposomal formulations containing proteins or small molecular drugs, as well as defining the optimal manufacturing …
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Characterization, Stabilization and Formulation Design of IgG and Secretory IgA Monoclonal Antibody Candidates during Storage and Administration
… storage, and administration. The use of formulation strategies, such as employing specific excipients and/or particular solution conditions (e.g., pH and buffers), can significantly improve a mAb’s pharmaceutical stability properties. In this Ph.D. thesis research work, both …
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Microstructural investigation of tablet compaction and tablet pharmacological properties
… this gap presents a barrier to rational formulation / process design. In this study, it was hypothesized that the understanding of tablet microstructure is pivotal in bridging our knowledge about the materials, the manufacturing process, and the tablet properties. A series of X-ray micro …
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High Resolution Mass Spectrometric Approaches To Study Protein Structure and Environment in Lyophilized Solids
… to improve stability. The lyophilized formulation may still undergo degradation during manufacture and/or storage. The mechanism of protein aggregation in lyophilized solids is not well understood or predictable by conventional analytical methods such as solid-state Fourier-transform …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
… soluble drug can be highly affected by its formulation design. In this respect, research on solid dispersion of hydrophilic carrier has commenced a decade ago to resolve the problem of poorly soluble drug. However, the availability of solid dispersion is commercially limited due to the …
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Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… solid dispersions is one of the most widely used formulation strategies for the enhancement of in-vitro and in-vivo performance of poorly water-soluble drugs. However, because of their meta-stable nature, the physical stability of amorphous solid dispersions has been considered to be the main …
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Towards Data-driven Development of Advanced Drug Formulations Leveraging Machine Learning and Experimental Automation
… be mitigated by developing fully optimized drug formulations. The development of these formulations usually involves extensive experimental work, starting with pre-formulation studies, followed by formulation design and optimization. Techniques, including molecular dynamics and design of …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… stages of pharmaceutical development, from formulation design to routine quality control. Its implementation ensures the consistent quality, performance, and regulatory compliance of medicinal products. For orally administered small-molecule drugs, in vitro testing has been extensively …
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Design and development of polymeric nanoparticles by continuous manufacture using twin screw extrusion
… ibuprofen (IBU) with Eudragit® EPO (EPO). The design spaces were predicted through Flory-Huggins (FH) based theory, and the selected ASDs were manufactured using extrusion to produce high-drug loaded ASDs (HDASDs). Secondly, the enhanced physical stability was further confirmed by high relative …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
… a low-stress process commonly used in parenteral formulations, enables the formation of amorphous matrices that immobilise peptides, restricting molecular mobility and mitigating degradation pathways. This thesis investigates lyophilisation as a core stabilisation strategy for oral insulin tablets …
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Factors that promote gender inequalities in Kapululwe Conservation farming project in Chongwe District
… stages of the project cycle especially in the formulation, design and implementation of community development project interventions. According to the findings of this study, these three issues coupled with poor National Gender Policy implementation have contributed to the perpetuation of gender …
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Factors that promote gender inequalities in Kapululwe Conservation farming project in Chongwe District
… stages of the project cycle especially in the formulation, design and implementation of community development project interventions. According to the findings of this study, these three issues coupled with poor National Gender Policy implementation have contributed to the perpetuation of gender …
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The rational design of drug crystals to facilitate particle size reduction. Investigation of crystallisation conditions and crystal properties to enable optimised particle processing and comminution.
… to achieve desirable quality attributes for formulation preparation and drug delivery remains a major challenge in the pharmaceutical sciences. It is therefore important that the relationships between crystal structure, the mechanical properties of powders and their subsequent influence on …
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Systems metabolic engineering through application of genome-scale metabolic flux modeling
… contents, analyzing their metabolism, and designing new capabilities. One of the most commonly used approaches in systems metabolic engineering involves genome-scale metabolic flux modeling. These models allow generation of predictions of the global metabolic flux distribution in the …
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Developability assessments and analytical characterization of recombinant protein antigens formulated as low-cost, multi-dose, aluminum-adjuvanted vaccines
… of recombinant subunit protein vaccines from a formulation perspective. In this work, a vaccine formulation developability assessment workflow was established to rapidly screen recombinant protein antigen variants using minimal material to identify optimally stable, low-cost vaccine candidates …
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Alternative design optimization formulations – developing and comparing for a vibration damping example
Developing mathematical formulations for design problems requires determining an objective function to compare design alternatives, a set of design features and options to be included for consideration, and a predictive model that reflect any unavoidable cause and effect relationships that are …