Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"formalin test"”.
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An analysis of the role of midbrain dopamine systems in the suppression of tonic pain
… acting in the midbrain induces analgesia in the formalin test for tonic pain. The present thesis explored in more depth the role of SP-DA interactions in the suppression of tonic pain, and examined whether the activation of midbrain DA neurons by endogeneous SP might be a mechanism underlying …
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Investigação da atividade psicofarmacológica do extrato etanólico bruto de Sargassum polyceratium em modelos animais utilizando roedores
… the time of paw licking in the second stage of formalin test (15 - 30 minutes). Motor c oordination, evaluated in rotarod test, has not been modified in the animals treated with SpEE in none of the doses. SpEE reduce d the time of paw licking in glutamate test, however it have not altered …
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Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models of Pain: Is Less More?
… 1, separate groups of Long Evans rats were tested for antinociception following an injection of vehicle, the cannabinoid agonist WIN 55 212-2 (WIN), the opioid antagonist naltrexone (an ultra-low or a high dose), or a combination of WIN and naltrexone doses. Ultra-low dose naltrexone …
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
… approved for use in humans have hindered testing beyond the preclinical stage. To address this issue I assessed the pain behavior of mice with a genetic absence of mGlu5. mGlu5 KO mice exhibit pain-like behaviors, however the duration and intensity of these behaviors are attenuated in …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… spontaneous behavior in the second phase of the formalin test, reduces inflammatory mechanical hypersensitivity, and eliminates heat hypersensitivity due to the inflammatory mediator, nerve growth factor: NGF). Nociceptive sensitization was not reduced in all models tested, since …
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Method development for investigating chemical distributions in the nervous system using mass spectrometry imaging
… the peripheral nervous system applied via the formalin test. Another study visualizes chemical distribution trends during planarian nervous system regeneration, revealing complex patterns in peptide content and distribution at different regeneration time points. In addition to traditional MSI, …
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Indagine sul coinvolgimento del sistema neuropeptidergico nocicettina/recettore NOP a carico della trasmissione nocicettiva
… la soglia nocicettiva nel ratto, rilevata con il test del tail-flick, a seguito di somministrazione diretta nello spazio subaracnoideo, in confronto con la nocicettina stessa. La somministrazione intratecale del neuropeptide nocicettina (10 nmol/ratto) ha determinato un innalzamento …