Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"forkhead"”.
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Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation
… to differentiation of Ch organs. fd3F encodes a forkhead transcription factor which has been identified as a potential downstream target of atonal in microarray experiments (Cachero et al., 2011). I have shown that fd3F is exclusively expressed in Ch neurons and their precursors in Drosophila …
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Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1
Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their …
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Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
… differentiation. Members of the FoxP family of Forkhead transcription factors are essential for normal T lineage development; Foxp3 is required for regulatory T cell generation and function, and Foxp1 is necessary for the development of native T cells. FoxP family member Foxp4 is highly …
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
… metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… and differentiate into memory T cells. The Forkhead box O transcription factors FOXO1 and FOXO3 (to lesser extent) are essential for naïve and memory T cell differentiation. However, FOXO1 and FOXO3 function is not restricted to quiescent T cells; there is increasing evidence for a role in …
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Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
… for the majority of cancer-related deaths. The forkhead box transcription factor FOXC2 is known to be involved in regulating metastasis as well as a variety of developmental processes, including the formation of lymphatic and cardiovascular systems. Previous studies have shown that FOXC2 protein …
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Control of M-G1 phase-specific expression in fission yeast
… transcription factors, Sep1p and Fkh2p, both forkhead-like transcription factors, and Mbx1p, a MADS-box protein, have been implicated in M-G1 specific gene expression and are thought to be components of PBF. Consistent with Fkh2p and Sep1p regulating M-G1 specific transcription, …
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Dissecting the function and targets of FOXG1 in glioblastoma
… the neural developmental transcription factor Forkhead Box G1 (FOXG1) as the most consistently overexpressed gene in GBM-derived neural stem (GNS) cells compared to their genetically normal neural stem (NS) cell counterparts. Here we explore the function and critical downstream effectors of …
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The significance of DAF-16 and its role in the phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes
… these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin–like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead …
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Sex Differences In Endothelial FoxO1 Response To Nutrient And Oxidative Stress
… favorable outcomes. Female ECs express higher Forkhead Box O1 (FoxO1) levels than males, suggesting sex-specific FoxO1 regulation. To explore this, male and female ECs were exposed to metabolic and oxidative stress, and FoxO1 subcellular localization and post-translational modifications were …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
… The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell populations active at sites of autoimmune pathology are not well characterized. To evaluate this, we combined global repertoire analyses and functional …
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Structural and functional analysis of a phospho-dependent molecular switch: Rv1827 from Mycobacterium tuberculosis
Forkhead-associated (FHA) domains have gained considerable prominence as ubiquitous phosphothreonine-dependent binding modules; however, their precise roles in Ser/Thr kinase pathways and mechanisms of regulation remain unclear. From experiments with Rv1827, an FHA domain–containing protein from …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… embryological approach, I demonstrate that the forkhead transcription factor Foxh1, a major transducer of Nodal signaling, associates with Gsc which in turn recruits histone deacetylases to negatively regulate Mixl1 expression during early mouse development. Post-translational modification of …
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Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
… a transcription factor in Manduca sexta known as Forkhead (MsFkh) that is involved in innate immunity. Lastly, Chapter 5 will summarize all data and foretell future perspectives.
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Determination of the main parameters affecting the performance of bridge falsework systems
… behaviour and resistance of spigot joints and forkhead joints (falsework to formwork interface) from which no published research was found. Existing joint models are evaluated and improved alternative models are developed. The results of numerical studies of a selected structural system are …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… describes the discovery of a role for the Foxo forkhead transcription factors in mouse spermatogenesis and SSCs. Foxo1 was found to specifically mark mouse gonocytes, and its cytoplasmic-to-nuclear translocation delineated the gonocyte-to-SSC transition in neonatal testes. In adults, Foxo1 is …
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Examining Sex Differences of Adipose Endothelial Cells and the Effects of Foxo1 Deletion
… quiescence-inducing transcription factor forkhead box O1 (FoxO1), which is more highly expressed in female ECs despite higher angiogenic activity. FoxO1 knockdown or inhibition in females led to a dysfunctional EC phenotype which was marked by inflammation, oxidative stress, impaired …
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Mechanistic and Physiological Studies of the Insulin-Dependent Regulation of FOXA2
<p>The Forkhead box A2 transcription factor (Foxa2/HNF-3β) has been shown to be a key regulator of genes involved in the maintenance of glucose and lipid homeostasis in the liver, and is constitutively inactivated in several hyperinsulinemic/obese mouse models, thereby enhancing their metabolic …
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Genetic analysis of endoplasmic reticulum homeostasis during stress and infection of Caenorhabditis elegans
… regulator. A mutation in the gene encoding the forkhead DNA binding domain-containing transcription factor FKH-9 enhances ER homeostasis outside the context of infection and immune activation, but paradoxically sensitizes animals to perturbations in cytosolic proteostasis. My results suggest …
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Identification of new genes and pathways that act to delay C. elegans aging
… converges with the insulin-like pathway on a forkhead transcription factor DAF-16. We discovered that 14-3-3 proteins play a role in C. elegans lifespan determination. 14-3-3 proteins interact with the SIR-2.1 protein, and the 14-3-3 genes par-5 andftt-2 are required for the longevity mediated …
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