Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"foreign-body"”.
-
In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers
The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 …
-
Modulating Neuroinflammation with Porous Templated Scaffolds
… performance remains unresolved. Via the foreign body reaction, macrophages and glial cells develop a “glial scar” around implants, increasing electrode impedance and leading to time-dependent declines in electrode performance. During the first two years of my PhD, I worked with Dr. Bill …
-
Untersuchungen zur extrazellulären Matrix unter Implantation differenter Netzmaterialien zum Bauchwandersatz
… pore vicrylmesh. The diameter of the resulting foreign body granulomas as a quantitative feature of the inflammatory reaction and the filament distance, on which a connective scar structure (scarred bridging of the pore) was analysed. Because in case of incisional hernia a disturbance of the …
-
Untersuchungen zur entzündlichen Fremdkörperreaktion an humanen Mesh-Explantaten unter Berücksichtigung von Risikofaktoren
… reaction in the organism with formation of foreign-body granulation interfering with the process of mesh integration. The present paper examines the expression of inflammation parameters CD68, TGFß1, Cox2 as well as the cell proliferation and apoptosis in the tissue of 86 mesh explants. It …
-
Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… a material, the immune system will initiate the foreign body response, a cascade of inflammatory activity resulting in material fibrosis. For encapsulated cell therapies, biomaterial fibrosis can result in diminished cell functionality or even cell death. To address this challenge, it is critical …
-
Multiphysics computational modeling of implantable actuable devices for local epicardial therapy delivery
… only one implantation surgery and reducing the foreign body responses through mechanical oscillation. In this thesis, we used different computational models (structural, drug diffusion, and fluid-structure interaction) to characterize the therapeutic effect of these two devices on the heart.
-
Microinvasive probes for the longitudinal interrogation of neural dynamics
… months of implantation. Chronic inflammatory and foreign body responses due to large implanted device size and mechanical mismatch are believed to be major contributors to signal degradation. In the first half of this thesis, I present the design of parylene-coated carbon fiber electrodes for …
-
Comparison of conjunctival pedicle flap to corneal adhesion achieved by Tisseel® fibrin glue, ethyl cyanoacrylate adhesive, ReSure® hydrogel sealant, and conventional suturing with 8-0 VICRYL® suture
… increased corneal edema, increased scar tissue, foreign body reaction, suture abscess and dehiscence. In human ophthalmology, a number of sutureless techniques to affix ocular tissues are being explored. Specifically, these approaches include synthetic tissue adhesives, bioadhesives, and hydrogel …
-
Funktionelle und histologische Auswirkungen von Mesh-Implantaten im Tiermodell
… the recurrence rates markedly. Disadvantages are foreign-body-reaction, infections, adhesions, local wound complications like seromas and restriction of mobility by the rigid "shell". Three different types of mesh materials are compared in a rat experiment: a heavy-weight monofilament …
-
3D BIO-PRINTED SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATION: AN INVIVO EVALUATION WITH FURTHER OPTIMIZATION
… marrow mesenchymal stem cells. No significant foreign body reaction was found. Scaffold extrusion and flattening was noticed in some subjects. Combining the scaffold with a Poly(ethylene) Glycol – Fibrinogen (PF) Hydrogel preliminarily improved bioactivity and catalysed cell differentiation. …
-
Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare
… These include weak adhesion with wet tissues, foreign body response, cumbersome application processes, and limited customizability. This dissertation presents a multiscale framework for addressing these obstacles, encompassing design strategies on the molecular, polymer network architecture, …
-
Bodies across borders : embodiment and experiences of migration for southern African international students at the University of Cape Town
… to heightened tensions around the meaning of a "foreign" body, this research questions the experiences of bodies crossing borders into the social and historical space of Cape Town, South Africa. Grounded in theories of surveillance, embodiment, and feminist geography of fear of crime, the study …
-
Peripheral Nervous System Modulation with Wireless Cellular Sized Freestanding Injectable Devices
… stimulation of excitable cells, to interface the body with electronics and treat a variety of diseases. Current technologies, while efficacious, are limited by their bulkiness, require highly invasive surgeries, are unable to target at single-cell level resolution and are prone to foreign body …
-
Molecular Insights into the Uropathogenesis of Enterococcus faecalis and Escherichia coli in the Context of Urinary Catheterization
… studies optimizing and using a rodent model of foreign body-associated UTI to mimic conditions of indwelling urinary catheters in humans underscored the importance of biofilm formation, although in vivo required only a subset of the identified in vitro biofilm-promoting factors such as sortases, …
-
Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS
<p>Biomaterial implantation induces the foreign body response (FBR). Development of longer-term implants relies on the thorough understanding of the FBR. The progression of the FBR is regulated by a number of biomolecules including cytokines, chemokines, and matrix metalloproteinases (MMPs). The …
-
Design of a Novel Video-Assisted Tube Over Tube Rigid Bronchoscope for the Removal of Foreign Bodies from the Bronchi Following Aspiration
Foreign body aspiration (FBA) is a prevalent occurrence in the paediatric population. FBA is when a foreign body (FB) is inhaled accidentally into the airways. The location of the FB may differ according to each patient, but in most cases, the FB is found in the right bronchial tree. FBA symptoms …
-
In-vivo-Untersuchungen zur Gewebeverträglichkeit einer neuartigen, leichtgewichtig-großporigen Mesh-Generation zur Narbenhernienreparation
… results confirmed an inflammatory proliferative foreign-body reaction within different cell-turnovers in the recipient tissues. These reactions are mainly influenced by the used mesh modifications. As result, the different Monocryl®-constructions showed a remarkable decrease in inflammation and …
-
Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
… involved in many biological responses. The foreign body response (FBR) is orchestrated by macrophages, wherein the phenotypes of these macrophages exist plastically along a spectrum from M1, proinflammatory macrophages to M2a, anti-inflammatory, pro-wound healing macrophages, and M2c, …
-
Multifunctional fiber-based neural interfaces
… probes and the neural tissues, which leads to foreign body response and functional device failure due to tissue scarring in the probe vicinity. To address the challenge, I developed fiber-based bioelectronic devices integrating diverse modalities within a single platform using thermal drawing …
Page 1 of 3