Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"forebrain development"”.
-
INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… generated from progenitors during early cortical development contribute to neuropsychiatric disorders. Genetic interventions are known to cause these disorders but underlying mechanism remains unclear. Human FEZ1 gene is associated with a few mental diseases. In this thesis, we seek to determine …
-
THE ROLE OF DMRT GENES DURING NEUROGENESIS IN THE ZEBRAFISH FOREBRAIN
… factors with important roles in sexual development as well as cell fate decisions in non-gonadal tissues. I aimed to analyse the roles of dmrt3 and dmrt5 during forebrain development in zebrafish. Here I show that dmrt5 is a critical regulator of neuronal differentiation in the fore- and …
-
Quantitative spatial transcriptomics of the developing brain
Developmental and cellular heterogeneity can be studied at the transcriptomic level using RNA sequencing methods, but techniques that quantitatively investigate the spatial dynamics of cell heterogeneity across large tissue areas at a single-cell level are lacking. Applying this capability to the …
-
The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… pathways and mechanisms utilized during brain development. In my thesis I present new and unexpected findings about neuronal migration in the developing forebrain. I analyzed and characterized a novel type of neuronal migration, so called tangential chain migration that was first identified in …
-
Redefining the Gastrula Organiser in Early Chick Embryo Development
… it can completely regenerate, and normal development follows. Previous observations suggest that a developmental delay occurs following organiser ablation, in both chick and frog embryos. We performed single cell RNA sequencing on node-ablated and control chick embryos during the first 5h …