Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"force-generation"”.
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Kinesin's force generation mechanism : study and practical application
… 5 (Eg5) constructs were used to study the force generation mechanism of the motor protein. The kinesin family of proteins walk along microtubules to carry cargo or pull microtubules along each other and do so by hydrolyzing a single ATP per 8nm step. The mechanism that is employed by …
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Synthesis of planar four-link mechanisms for force generation
… linkages to produce a specified resisting force or torque. Historically, mechanism force synthesis has assumed that output positions must always be associated with prescribed forces. This results in the loss of design parameters. Applications which do not require a specified output position …
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Upstream Migration Under Shear Flow: Force Generation and Molecular Regulation
… Despite the centrality of mechanical force to this process, the forces upstream-migrating cells generate at the cell-substrate interface have not been directly measured during sustained upstream migration, and the molecular machinery responsible for producing them remains …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
… to develop a novel method for probing traction forces during chemotaxis. We find DC migration is driven by short-lived traction stresses at the leading edge or filopodia. We illustrate that spatiotemporal pattern of traction stresses can be used to predict changes in the direction of DC motion. …
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Coordination of cellular force-generation during Drosophila ventral furrow formation
… both embryonic development as well as tissue regeneration. An open question is how individual cells collectively generate force to achieve the correct tissue architecture. This thesis examines how the apical forces generated by Drosophila ventral furrow cells undergoing collective apical …
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Planning for Army Force Generation Using Lot Streaming, and Extensions
As the Army transitions to the Army Force Generation (ARFORGEN) deployment cycle, it must adjust its many operations in support of ARFORGEN. Specifically, the Initial Military Training (IMT) must be able to adjust the scheduling of its classes for newly enlisted service members to finish training …
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OPTIMIZATION OF THE FORCE GENERATION PROCESS OF MARINE CORPS INFANTRY BATTALIONS
The Marine Corps' Force Generation Process (FGP) requires multiple inputs to generate the combat forces necessary to accomplish the goals set in the National Defense Strategy (NDS). Current manpower assignment methods do not optimize the manning of Marine Corps infantry battalions to ensure maximum …
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Motility and Force Generation Based on the Dynamics of Actin Gels
This thesis explores the force generation of actin gels and their famous pro-pulsion mechanism leading to active motility on the cellular scale. In nature the generation of force and motility is regulated by actin binding proteins and the mesoscopic shape of the gel. Here we controlled an analyzed …
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Mechanics of axonal force generation in embryonic Drosophila neurons in vivo
… provided new evidence of the role of mechanical forces in the functioning of neurons in vivo. These experiments have revealed that vesicle clustering in the presynaptic terminal of the neuromuscular junction in Drosophila embryos is dependent on mechanical tension in the axons. Vesicle clustering …
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In vitro pharmacological inhibition of myofibroblast differentiation and force generation in a collagen-GAG matrix
Induced regeneration studies from three organs in the adult mammal (skin, peripheral nerves, and the conjunctiva) suggest an antagonistic relationship between myofibroblast-mediated contraction of wounds and induced regeneration. In each instance of induced regeneration, contraction blocking was …
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Force regulation in contractile cells by chemical and mechanical signaling
… signals can promote disease states by altering force generation. It is cru- cial that we understand how these signals affect force generation and the implication of that force in health and disease. We approach this by investigating cells from two types of tissues: heart tissue cells and …
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Comparing Shoulder Manual Muscle Testing With Scapular Retraction And Core Activation
<p>The kinetic chain plays a large role in the force production of the body during activity. The core and the scapula are critical kinetic chain links to the upper extremity during overhead motions and should likely be accounted for when performing manual muscle testing of the shoulder. The purpose …
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Molecular analysis of kinetochore-microtubule attachment in budding yeast
… kinetochores act to couple microtubule force generation to chromosome movements. Microtubule associated proteins are also thought to play a key role in this process by regulating plus-end microtubule dynamics and tensile force generation. However, the actual molecular mechanism of force …
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Using Kinetics to Determine Slip Probability in a Movement Associated with a High Risk of Slip Occurrence
… to evaluate only one component, horizontal force, of the current friction calculation. The purpose of this dissertation was to determine if horizontal force generation would serve as a more accurate predictor of slip probability for movements associated with a high-risk of slipping; a 90° …
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Effects of seated posture on static strength, lower-body isometric muscle contractions, and manual tracking performance
… of the following variables: (1) static force generation capabilities on an isometric force-stick; (2) lower-body isometric muscle contractions used in anti-gravity straining maneuvers (AGSMs); and (3) tracking performance for a manual tracking task. The purpose of this research is to …
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Chemomechanics at the cell-material interface : measurements and implications of forced molecular unbinding
… characterization of cell surface structure and force generation are realized via various atomic force microscopy (AFM) imaging techniques including AFM cell force spectroscopy and functionalized force imaging. In these approaches, the recognition of mechanical responses of cells or mapping of …
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Factors that influence the performance of hop tests
… Projection Angle (FPPA), balance tests, force generation tests, and isokinetic strength testing to establish the measurement error of these. The findings of first study revealed that the majority of the intraclass correlation coefficients (ICC) values for all tests were excellent across …
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The development and characterization of soft robotic contractile actuators
… would be required to generate physiological force for blood ejection. However, McKibben PAMs with thermoplastic polyurethane (TPU) bladders were too bulky and prevented the embedding of additional actuators. Therefore, multiple alternate PAM designs which occupy minimal unpressurized volume …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
… in generating TCR-driven contractile forces is then investigated through use of micropillar arrays. This approach also enables the quantification of forces generated by T cells during cellular activation. The impact of CD28 costimulation on TCR-driven force generation is assessed and …
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Exercise induced pain and damage in human skeletal muscle
… was assessed by studying changes in isometric force generation, muscle enzyme loss, morphological changes and the patterns of radioisotope uptake. Delayed onset muscle pain occurred after eccentric but not concentric contractions and was associated with appreciable muscle damage. A technique …
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