Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"force transduction"”.
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Cells and force transduction
… thesis studies mechanism involved in propagating force generated at cadherin complexes. The first part of this thesis demonstrates that mechanotransduction at classical cadherin complexes is not only ligand-dependent but also dependent on the respective receptor tyrosine kinase (RTK) binding …
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Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes
… and their role in mediating E-cadherin mechanotransduction. E-cadherin serves as molecular Velcro in epithelial cells to maintain epithelial homeostasis. Despite passively bearing mechanical stress at cell-cell junctions, E-cadherin has been shown to actively respond to force to reinforce …
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Mechanotransduction at cell-cell contacts
… recent findings that cadherin complexes are also force transducers, and addresses whether differences in cadherin affinity also differentially alter cell mechanics. Studies discovered a significant difference between force transduction triggered by homophilic versus heterophilic cadherin bonds …
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E-cadherin mechanotransduction beyond cell-cell junctions
… identified biochemical processes and signal transduction pathways in cadherin-based mechanotransduction. In this thesis, I investigated the role of E-cadherin in mechanotransduction, using modified Magnetic Twisting Cytometry (MTC) and Traction Force Microscopy (TFM) coupled with fluorescence …
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Dynamics of Cellular Rigidity Sensing on the Micron and Sub-micron Scale
… of the cellular environment on cellular force and force transduction. Different mechanical parameters such as geometry and rigidity of the substrate are controlled independently and forces exerted by cells were measured. The experimental system for this study is based on fabrication of …
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Structual Visualization of Cytoskeletal Force Tranduction
… environments. This enables contractile forces generated by myosin motors to mediate transduction of mechanical cues into biochemical signaling pathways by unclear mechanisms. In this thesis, I show that myosin forces elicit conformational transitions in actin filaments (F-actin) that …
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EGF receptor-mediated fibroblast signaling and motility : role of nanoscale spatial ligand organization
… bound within the extracellular matrix to permit force transduction by the cell, the canonical view of growth factors is of soluble molecules freely diffusible and internalizable by the cell. Recent evidence suggests that in some cases growth factor receptor ligands may be embedded in the …
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Combined optical trapping and single molecule fluorescence to study the force-dependent binding kinetics between filamentous actin and its partners
… body to the focal adhesions in order to transmit forces into and out of the cell. During the force transduction process, many proteins bind to actin filaments in order to initiate a signaling cascade that reaches the cell nucleus. However, the effects of forces in the binding kinetics between …
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Polymer architecture effects on mechanochemical reactions
… highly extended in elongational flow fields. The forces developed along the backbone give rise to scission of the chains near their center. Recently, this unique property of polymers has been adopted to explore new chemical transformations by embedding structural elements into the backbone …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
… evidences supporting the notion that mechanical forces are crucial in regulating the physiologic functions of cells and tissues. The importance of engineering principles in studying the biological behavior of cells is no longer in question. Instead, much research is now focused on how mechanical …
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Structural Mechanisms of F-actin Mechanochemical Regulation and Flexible Network Assembly
… by both biochemical processes and mechanical forces. The mechanisms mediating this interplay remain unclear at the protein structural level. Newly polymerized F-actin hydrolyzes bound ATP to produce metastable ADP-Pi–F-actin, which persists for minutes before phosphate release to yield …