Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"force extension"”.
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Force-extension of the Amylose Polysaccharide
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory …
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An Approach to Analyzing and Predicting Force-extension Curves of Nucleic Acids
… experiments reveal a distinct plateau region in force-extension curves of nucleic acids such as long double-stranded deoxyribonucleic acids (DNA) and ribonucleic acids (RNA). The dissertation comprises two parts. In the first part, we propose an approach to help analyze polymer force-extension …
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Single Molecule Force Extension Measurement on Semi-Flexible Biopolymers Using Magnetic Tweezers
… an inverted fluorescence microscope. Magnetic forces in the piconewton range are applied to individual DNA molecules, and the relative chain extension due to applied force is directly measured and shown to be between 15% and 75% of the polymer contour length (16.3 µm for lambda-phage DNA). The …
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Force-response statistics of semiflexible polymers
… on their mechanical responses to a variety of forces, and these responses are governed by their physical properties. A variety of single-molecule force-extension experiments have allowed the manipulation of biomolecules to probe the physical properties of these biopolymers in unprecedented …
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Experimental Strength Characterization of Epoxy Double Lap Joint for Carbon-Fiber Reinforced Polymer Tube
… universal testing machine for gathering of force-extension measurements as the joints were tested to failure. The stiffness of the off-the-shelf tubes was also experimentally determined to allow for the calculation of the theoretical critical load to fail the joint, according to a flat-plate …
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Parameterized Shape Adaptive Material: A New Design Method for Inclusive Sportswear
… these shape adaptive composites based on desired force-extension curve parameters. Experimental testing is completed to validate the predictive model portion of the optimization tool and shows good agreement in mid-range (aˆ=0.3 & 0.4) designs, with some noted inconsistencies in lower range values …
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Some Investigations Of Phase Transitions In Rod-Like Macro-Molecules And Fibrous Gels
… temperature bath and show that the resultant force-extension relation matches very well with the Langevin dynamics results. We estimate the force fluctuations at the pulled end of the bar due to thermal kicks from the bath by using a partition function. We also show rate dependence of …
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Microstructurally-based constitutive models of cytoskeletal networks for simulation of the biomechanical response of biological cells
… continuum mechanics approach. The force-extension behavior of the individual filaments is captured with a new analytical expression of the MacKintosh worm-like chain relationship for semiflexible filaments. The filament expression is used in the Arruda-Boyce eight-chain network …
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Anharmonic Acoustic Technique for Detection of Surface-bound Particles
… presence of weak electrostatic and Van der Waals forces between the receptor and the non-target substances in the analyte that are not easily dissociated in practice. Most existing detection techniques are unable to probe the interaction between the bound entity and the surface and differentiate …
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Development of a State-of-the-Art Atomic Force Microscope for Improved Force Spectroscopy
… the development of a state-of-the-art atomic force microscope (AFM) for improved force spectroscopy. Although the AFM has been used extensively in this field of research, the performance of the instrument has been limited by inefficient operation techniques, incorrect experimental assumptions, …
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Biomechanical structure-function relationships of collagen tissues, B Cell membranes, and amyloid fibers
Mechanical forces are critical to defining the physiological function of biological systems spanning length scales from 1 nm (single molecules) up to 1m (full mammalian systems). This work combines theoretical and experimental mechanics to gain insights into the physiological function of three …
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Towards Synthetic Molecular Motors Interfaced by AFM
… In this thesis, AFM-based single molecule force spectroscopy (S M FS) was utilized to investigate the mechanical change in single synthetic molecules upon environmental changes (external stimuli) in liquid environment at room temperature. The molecules are either from theory or from bulk …
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Structural and mechanical properties of intermediate filaments under extreme conditions and disease
… filament proteins play key roles to reinforce cells subjected to large-deformation as well as participate in signal transduction. However, it is still poorly understood how the nanoscopic structure, as well as the biochemical properties of these protein molecules contribute to their …
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Understanding Chromatin Organization and Dynamics with Coarse-Grained Modeling
… we demonstrate the development of CG simulation force fields and toolkits. In Chapter 2, we present novel CG force fields trained with contrastive learning. We have achieved a new set of hydropathy parameters trained with a99SB-disp all-atom force field trajectories of intrinsically disordered …
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Multi-domain Protein Unfolding Pathway Studies by Single Molecule Techniques
… origin of the signal from single molecule force spectroscopy (SMFS) based on atomic force microscopy (AFM) can be directly identified. Beyond this published work, I also characterized and compared the unfolding pathway of two homologous multi-domain proteins – yeast phosphoglycerate kinase …
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Interactions between nucleoid associated proteins and DNA in the presence of mechanical and chemical forces
… interactions that result in concentration-, force-, and topology-dependent changes to both protein kinetics and physical DNA behavior. Our model qualitatively matches experimental observations, and provides a physical explanation for the observed behavior based on cooperative local …