Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"food effect"”.
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Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects
… a population pharmacokinetic approach, quantify food effects, drug combinations and pharmacological effects. The population pharmacokinetics of rifampicin, isoniazid and pyrazinamide in 76 children with tuberculosis were described using a population pharmacokinetic approach, and then Monte Carlo …
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Computational pharmaceutics approaches to inform drug developability: focus on lipid-based formulations
… regression outputs, were developed to predict food effect on bioavailability, solubility ratio (SR) upon self-emulsifying drug delivery system (SEDDS) dispersion and apparent degree of supersaturation (aDS) ratio in supersaturated LBFs (sLBF). Model performance was validated using test sets or …
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Exploring the utility of the pig model for predicting bioavailability in humans
… In addition, the ability of predicting food dependent bioavailability was assessed for both compounds. The formulations were evaluated in vivo in landrace (LR) pigs. Followed by a post-mortem assessment of the gastrointestinal (GI) fluids, to assess fasted and fed study protocols. …
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Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin
… treatment of hypercholesterolemia and exerts its effect through targeted accumulation in the liver. Current United States and Canadian dosing guidelines indicate no preference for fed or fasted rosuvastatin administration. In this study, we demonstrate for the first time that concomitant …