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Showing 1 to 20 of 108 for “"folic acid"”.
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The effect of continued folic acid supplementation beyond the first trimester on unmetabolised folic acid in late gestation
Folic acid (FA) is the synthetic form of the vitamin folate. Pregnant women are advised to take FA supplements before conception and during the first three months of pregnancy to reduce their chances of having a neural tube defect (NTDs) affected pregnancy, severe birth such as spina bifida and …
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Folic Acid Intake, Maternal Obesity and Neural Tube Defects
… defect (NTD) and to study relationships between folic acid intake during the periconceptional period and the risk of NTD in overweight and non-overweight women.</p> <p>"Methods:" We used data from a state-wide case-control study conducted between 1992 and 1997 in South Carolina. Overall, 179 …
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Folic acid in preventing recurrence of colorectal adenomas : is it effective?
… agent against the development of these lesions. Folic acid was found to be beneficial for various health reasons and also was believed to have an association with the improvement in the DNA methylation of the inner wall lining of the bowel. Therefore the proposed research question for this …
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Transport of Folic Acid and Related Compounds Across the Small Intestine
The intestinal transport of folic acid (pteroyl-L-glutamic acid) was investigated using in vitro preparations of rat jejunum. It was established that folic acid is accumulated in the gut wall and transported into the serosal compartment by a saturable mechanism. The kinetic parameters and the …
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The Fate of Folic Acid and Related Compounds in the Rat
… At doses of 22 and 320ug of pteroyl-L-glutamic acid/ kg, 50 and 25% respectively was absorbed, With doses of 320ug of [214-C]pteroyl-L-glutamic acid/kg, radioactivity was detected in the peripheral circulation 10 minutes after administration. Pteroyl-L-glutemic acid was absorbed without …
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The relationship of folic acid compounds to one-carbon metabolism in the tabacco plant
Thesis (M.S.)--Michigan State University of Agriculture and Applied Science. Dept. of Chemistry, 1958
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Design of folic acid, transferrin, and integrin receptor specific polyamidoamine dendrimers for gene delivery
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-06-14T15:37:18Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Hwang_Mark.doc: 55420928 bytes, checksum: 0010b064d38a25a15d06deb51af67ca4 (MD5) Hwang_Mark.pdf: 22852276 bytes, checksum: …
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The bioavailability of folic acid in pectin - coated fortified rice in humans using stable isotope techniques
… of the pectin-coated rice premix gave folic acid coating and cooking losses of 33.5% and 15.5% respectively. The mean test dose error per 400μg folic acid was ± 26 μg. Single- or tri- enzyme extraction of fortified rice extracts did not significantly increase the mean assayable folate …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… aim of this research project is to develop folic acid targeted nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that affect the posterior segment. Etoposide (ET) is used for treatment of retinoblastoma …
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Investigating the Receptor Interactions and Mechanisms of a Folic Acid-Conjugated Nanoparticle in the Treatment of Breast Cancer
… critical for targeted treatments to work. The folic acid receptor alpha (FRα) has gained popularity as a potential target in triple-negative breast cancer (TNBC). We have previously reported on a functionalized folic acid (FA)-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic …
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Synthesis and Characterization of Thermally Responsive Nanocapsules Surface Decorated With Folic Acid For Targeted Drug Delivery and Cancer Destruction
… delivery, we have surface-modified them with folic acid (FA, to target folate receptor overexpression in cancer cells) and/or polyethylene glycol (PEG, for stealth to minimize opsonization in serum). The surface-modified nanocapsules are thermally responsive in size, which enables …
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Perception and understanding of Pregnant Women towards the use of Folic Acid Supplement׃ the Case Study of Temeke District
… of pregnant women towards the use of folic acid supplement. The study was conducted at Temeke District in Dar es Salaam region. Data were collected using Focused Group Discussion as well as In-depth interview. The study reveals that most of women were aware of the FeFo supplement given …
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Release, Stability and Functionality of Nanodelivered Hydrophobic (Lutein and Beta-Carotene) and Hydrophilic (Folic Acid) Antioxidants Using Zein Nanoparticles
… simulated gastrointestinal environments. Lastly, folic acid modified zein nanoparticles sustained the release of folic acid, showed a good biocompatibility, and diminished the toxic effect of folic acid on cells. The increased uptake, particularly by the over-expressing folate-receptor cells …
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The role of folic acid supplementation on exencephaly induced by maternal exposure to sodium valproate in the TO mouse
Valproic acid (WA) is an anticonvulsant drug known to cause spina bifida in humans and exencephaly in animals. The Theiler Outbred (TO) mouse exhibits a low incidence (4.4%) of spontaneous exencephaly at birth. This frequency is enhanced by sodium valproate (VPA), an anticonvulsant drug. Earlier …
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An assessment of the effects of dietary folic acid supplementation on serum folates status, conceptus development and reproductive performance in gilts and sows
The effects of dietary folic acid supplementation on serum folate status, conceptus development and reproductive performance in gilts and sows was investigated in a series of experiments. The specific objectives of the study were to: 1) to study the serum folates profile following rapid consumption …
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Studies in the Folate Metabolism of Rats
The metabolism of 2-14C folic acid was studied in three-week-old weanling Wistar rats. Distribution of radioactivity after an oral dose of 2-14C folic acid was determined in urine, faeces, liver, and gut of the animals. Some of the urinary metabolites were characterized by column chromatography. …
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The Role of Surface Properties in the Transport of Folates Across the Intestine
… the glycocalyx acts as a retaining layer for the acid microclimate on the jejunal mucosal surface. Histological investigation of human jejunal biopsies from healthy volunteers and patients with gastrointestinal disease showed an abnormality in the glycocalyx of subjects with conditions associated …
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