Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"folding machinery"”.
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A novel in vivo protein refolding technique
… functions in their native folded states and misfolding of proteins may cause severe diseases, including Alzheimer's disease, Parkinson's disease, prion disease and diabetes. Understanding protein folding is important for us to engineer proteins to treat these diseases. For protein therapeutics, …
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Untangling Genomes from Metagenomes
… hosts over control of essential archaeal protein folding machinery in the euryarchaeal host cell. Whether marine Euryarchaeota will ever be isolated into culture remains unknown, but through the use of metagenomic genome assembly, key details about how they survive--and perish--in the world's …
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Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
… as byproducts from the oxidative protein folding machinery in the ER, especially during an unfolded protein response (UPR). Using a beta-cell line (MIN6) and mouse islets, endogenous production of ROS, the GSH/GSSG couple, and expression of genes involved in oxidative protein folding …
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Defining the functional response of Mycobacterium sp. infected macrophages to structural variants of Interferon gamma (IFN-y)
… consistent with the influence of eukaryotic folding machinery and post-translational context. These observations underscore the importance of expression-host selection when producing structurally representative recombinant cytokines. Overall, this study supports an ensemble-based view of …
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Stress-signal recognition in the unfolded protein response
… protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER) by adjusting its folding capacity to the load of unfolded proteins in the compartment. This critical feedback mechanism governs the functioning of the secretory pathway, impacting various …
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The Role of CASK in Central Nervous System Function and Disorder
… in humans. CASK is an enigmatic multi-domain scaffolding protein which plays a vital role in organizing protein complexes at the pre-synapse through interactions with both active zone proteins and trans-synaptic adhesion molecules such as liprins-α and neurexins. Mutations in the X-linked CASK …
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MOLECULAR MECHANISMS ORCHESTRATING LYSOSOME-MEDIATED DEGRADATION OF RIBOSOMES IN ANEUPLOID CELLS
… at multiple levels in aneuploid cells. Protein folding, for instance, is known to be compromised and this feature together with the overwhelming of quality control mechanisms leads to the accumulation and aggregation of not-properly folded proteins in the cytoplasm. The pathway that is in charge …
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Evaluation of the immunomodulatory activity of Plasmodium falciparum hsp70-1
… the cell’s molecular chaperone system (protein folding machinery). Plasmodium falciparum Hsps play an important cytoprotective role ensuring that the malaria parasite survives under the harsh conditions that prevail in the host environment. P. falciparum Hsp70-1 (PfHsp70-1) is a ubiquitous, …