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Showing 1 to 3 of 3 for “"fold superfamily"”.
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The early history and emergence of molecular functions and modular scale-free network behavior
… motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (EFL) sequences and domain structures defined at the fold superfamily (FSF) level of Structural Classification of Proteins (SCOP). The resulting ‘elementary …
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Characterization of the Plant CXE Carboxylesterase Family
… with members of the α/β hydrolase fold superfamily. Phylogenetic analysis of the plant CXE genes distinguishes eight distinct clades. Detailed examination of the A. thaliana genome reveals that the AtCXEs are widely distributed across the genome, being present in four out of five …
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A dynamic model for the evolution of protein structure
… of a protein determines its function, it is the fold, much more than the underlying protein sequence and underlying chemistry, that is evolutionarily conserved. We are interested in probing the history of life with these domain structures and glimpsing qualitative changes over time by studying a …