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Showing 1 to 14 of 14 for “"folate deficiency"”.
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Base excision repair, folate deficiency and cancer
<p>Folate, an essential water soluble vitamin has been implicated in the etiology of many types of cancer especially colorectal cancer. Folate deficiency has been reported to incapacitate DNA repair pathways and thereby affect the genomic stability. Our lab has reported previously and here again …
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Folate Deficiency and Its Effect On Dna Repair
<p>The effect of folate on cancer prevention has been examined in a number cellular and epidemiological studies, yet unanswered questions remain. For example, recent studies raised questions regarding the timing of folic acid supplementation. High folate status tends to have a protective effect …
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Interactions between Folate Deficiency and β-Nicotinamide Adenine Dinucleotide Deficiency and Conformational Study of Thymidylate Synthase and its Physiological Relevance
… pathways leading to TTP or methionine synthesis. Deficiency of MTHF or imbalance in the pathways utilizing MTHF may cause uracil incorporation into DNA and/or a decrease in one-carbon groups required for DNA methylation. The default pathway for excision of uracil in DNA is the base excision repair …
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An investigation into folate deficiency in healthy underprivileged infants with special emphasis on the interpretation of the Figlu test after oral histidine
In South Africa, as: in other countries with a large underprivileged population group, the problem of malnutrition and its- associations and complications assumes considerable importance. Until the socioeconomic problems involved are solved, attention must be directed to early diagnosis, treatment …
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The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to dna damage and imbalanced repair
<p>The condition of folate deficiency has been implicated in carcinogenesis, with the strongest evidence formulated in colon cancer. The role of folate in DNA repair, DNA synthesis and methylation reactions renders this nutrient an valuable target for studying the onset and progression of cancer. …
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Diet, genetic and epigenetic signatures in women of childbearing age from a Mediterranean population: perspectives for public health
… the association between Mediterranean diet (MD), folate intake and global DNA methylation in women of childbearing age. A total of 177 women were enrolled in a cross-sectional study. Folate intake and MD were assessed by a validated food frequency questionnaire. LINE-1 methylation level in …
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The Role of Surface Properties in the Transport of Folates Across the Intestine
… epithelial cell glycocalyx in the transport of folates in the intestine has been demonstrated. It was proposed that the glycocalyx acts as a retaining layer for the acid microclimate on the jejunal mucosal surface. Histological investigation of human jejunal biopsies from healthy volunteers and …
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Uracil Accumulation Response To Folate Depletion Is A Function Of Dna Repair Imbalance That May Be A Mechanism Of Aging
<p>Folate is an essential nutrient for human. They carry and transfer one carbon units. They has important biological functions during many reactions, like DNA synthesis, RNA synthesis, DNA methylation, DNA repair, cell division and growth. Through biochemical techniques to determine the gene …
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Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia
Vitamin B12 and folate deficiency is a well-known health problem. Deficiencies of folic acid and vitamin B12 are known to cause megaloblastic anaemia, which is characterised by presence of abnormally large erythrocyte precursor cells, megaloblasts, in the bone marrow and macrocytic red cells in the …
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Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia
Vitamin B12 and folate deficiency is a well-known health problem. Deficiencies of folic acid and vitamin B12 are known to cause megaloblastic anaemia, which is characterised by presence of abnormally large erythrocyte precursor cells, megaloblasts, in the bone marrow and macrocytic red cells in the …
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Modulation of RNA Cytosine-5 Methylation by Neuronal Activity and Methyl-donor Folate
… In chapter 3, we investigate the effect of folate, a methyl-donor, on RNA cytosine-5 methylation (5-mrC) modification in adult mouse neural stem cells (NSCs). Compared to the control, NSCs cultured in folate deficiency or supplementation condition have shown no changes in mRNA expression, …
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Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
… and progression of colon cancer when dietary folate is deficient. Both cellular folate restriction and BER deficiencies have been shown to result in the accumulation of endogenous damage and lesions that could eventually develop into carcinogenesis. In this study, a dietary folate deficiency …
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Folate Metabolism in Normal and Tumour Bearing Mammals
… metabolism and physiological disposition of folate derivatives has been studied in normal and tumour bearing rodents. Within 48 h of administration of radioactive folate tissue radioactivity was incorporated largely into high molecular weight folate conjugates. The major derivative was …
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Multigenerational effects of abnormal folate metabolism on embryo growth and development
It has been known for decades that maternal folate deficiency impairs fetal development. However, the molecular mechanism of folate metabolism remains unclear. To explore this, we study a mouse model of abnormal folate metabolism whereby the gene Mtrr was mutated causing a knockdown effect. MTRR is …