Global ETD Search
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Showing 1 to 5 of 5 for “"folate biosynthesis"”.
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
… challenges. The mechanisms of resistance to folate biosynthesis inhibitors in Staphylococcus aureus were explored from a genetic, biological, biochemical, and structural basis. Unexpected roles in resistance and fitness were attributed to various mutations in the sulfonamide target …
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The mechanistic basis of susceptibility and resistance to the antitubercular drug para-aminosalicylic acid
… of action of PAS on the M. tuberculosis folate metabolic pathway; 2) Understanding the mechanisms of PAS resistance; and 3) Examining the drug-drug interactions between PAS and other anti-folate drugs that are used to treat opportunistic infections in patients with HIV-M. tuberculosis …
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CT610: A Mn-Dependent Self-Sacrificing Oxygenase in p-Aminobenzoate Biosynthesis in Chlamydia trachomatis
Folate is an essential cofactor required for several processes including DNA and amino acid biosynthesis. Folate molecules are made up of three parts: a pteridine ring, p-aminobenzoate (pABA), and a variable number of glutamate residues. Chlamydia trachomatis synthesizes folate de novo; however, …
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Biochemical Characterization of Self-Sacrificing P-Aminobenzoate Synthases from Chlamydia Trachomatis and Nitrosomonas Europaea
Tetrahydrofolate (THF) is an essential cofactor for one-carbon transfer reactions in various biochemical pathways including DNA and amino acid biosynthesis. This cofactor is made up of three distinct moieties: a pteridine ring, p-aminobenzoate (pABA), and glutamate residues. Most bacteria and …
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Structure- and Ligand-Based Design of Novel Antimicrobial Agents
… to form pteroic acid as a key step in bacterial folate biosynthesis. It is the traditional target of the sulfonamide class of antibiotics. Unfortunately, bacterial resistance and adverse effects have limited the clinical utility of the sulfonamide antibiotics. Although six bacterial crystal …