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Showing 1 to 20 of 192 for “"folate"”.
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Folate status and milk folate concentration in lactating women
Lactating women have an increased requirement for folate which contributes to their risk for suboptimal folate status. Although milk folate secretion appears to be maintained independent of folate intake and maternal folate status, studies with animal species have demonstrated a relationship …
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Folate Absorption Across the Colon and the Modulation of Bacterial Folate Synthesis by Diet
While assessment of folate requirements has been based only on dietary intakes, folate produced by the colonic microflora can exceed amounts consumed in food. Bacterially synthesized folate is absorbed across the rat and piglet colon. In vitro studies suggest, but direct evidence is lacking that …
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Folate: Friend or Foe? An investigation into the opposing roles of folate in glioma
… in glioma cells, but methylating agents such as folate, may reverse aberrant methylation. Folate treatment has shown a beneficial effect, reducing risk of certain cancers (colorectal, breast, squamous cell carcinoma) but other studies have shown detrimental results whereby proliferation of cancer …
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Bioavailability studies of folate in humans.
Bioavailability studies of folate in humans.
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Immunotherapy of Folate Receptor Expressing Cancers
The folate receptor (FR) is a GPI anchored cell surface glycoprotein that functions to facilitate folic acid uptake and mediate signal transduction. With the introduction of multiple folate-targeted drugs into the clinic, the question has arisen regarding how frequently a patient can be dosed with …
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Folate Metabolism in the Guinea Pig
… product) were found in the urine. No radioactive folate was excreted except at very high doses when trace amounts of folic acid appeared, or after pre-treatment of the guinea pigs with antibiotics or methotrexate. Up to 20% of an oral dose of (2~14c] folic acid was found in the expired air. Only …
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Base excision repair, folate deficiency and cancer
<p>Folate, an essential water soluble vitamin has been implicated in the etiology of many types of cancer especially colorectal cancer. Folate deficiency has been reported to incapacitate DNA repair pathways and thereby affect the genomic stability. Our lab has reported previously and here again …
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Studies of Folate Catabolism in the Rat
… folic acid to various compounds. Intact folates and catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and …
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Biosynthesis of folate polyglutamates in the rat
The biosynthesis of folate polyglutamates and the disposition of the folate monoglutamate pool have been investigated in the tissues of normal and tumour-bearing rats following the oral administration of radio labelled folic acid. The principal folate monoglutamates detected were identified as …
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Studies in the Folate Metabolism of Rats
… methotrexate-treated animals. 10-Formyltetrahydrofolate and p-aminobenzoyl-L-glutamate were the other major metabolites present in the urine. The major metabolite in the urine of control rats was characterized as 5-methyltetrahydrofolate. The metabolism of 5-14C methyltetrahydrofolate was also …
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Interaction of iron and folate during reproduction
… severely or moderately iron-deficient dams were folate depleted at day 17 of lactation even when maternal animals were fed twice the National Research Council's recommended amount of folate (J. Nutr. 117: 1715; J. Nutr. 113: 2471). Folate status of iron-deficient (Fe$-$) pups at day 2 were …
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Folate Status and Supplementation in the Horse
… effects of lactation, exercise, and anti-folate drugs on folate status in the horse, and the bioavailability of supplement and feed folate in the horse. In the first study, mares and foals had adequate plasma folate, RBC folate, and plasma homocysteine concentrations during 6 mo of …
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Folate Deficiency and Its Effect On Dna Repair
<p>The effect of folate on cancer prevention has been examined in a number cellular and epidemiological studies, yet unanswered questions remain. For example, recent studies raised questions regarding the timing of folic acid supplementation. High folate status tends to have a protective effect …
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Folate Metabolism in Normal and Tumour Bearing Mammals
… metabolism and physiological disposition of folate derivatives has been studied in normal and tumour bearing rodents. Within 48 h of administration of radioactive folate tissue radioactivity was incorporated largely into high molecular weight folate conjugates. The major derivative was …
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Etiology of orofacial clefts, gene-environment interactions and folate
Contains fulltext : 146928.pdf (Publisher’s version ) (Open Access)
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Folate transport and drug resistance in the African Trypanosome
… of the mechanism of action and resistance of antifolate drugs in African trypanosomes with a specific focus on transport mechanisms. A media deficient in folate and thymidine was established which enabled the assessment of their modulation on antifolate in vitro potencies and also screen a small …
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Studies of Folate Metabolism in Man and the Rat
… is metabolised to vartous compounds. Both intact folates and folate catabolites were excreted in the urine after administration and folate polyglutamatesfound in the tissues. The relative amounts of intact folates and folate catabolites varied with time and dose. The results presented support the …
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The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]pyrimidine Antifolates"
… <p>Approximately 90 percent of EOC are folate receptor alpha (FRα) positive with the extent of receptor over-expression corresponding with stage and grade of disease. FRα based therapies are a subject of increasing interest warranted by a growing number malignancies, from various tissue …
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