Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"focal ischemia"”.
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Mechanisms of translation arrest following focal brain ischemia
<p>MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN</p> <p>ISCHEMIA</p> <p>by</p> <p>MONIQUE K. LEWIS</p> <p>August 2011</p> <p>Advisor: Dr. Donald DeGracia</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The loss of blood flow to the brain is termed ischemia and the …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… middle cerebral artery (MCA) after experimental focal ischemia and a similar upregulation is also seen after organ culture of MCA. Furthermore, studies have shown an involvement of protein kinase C (PKC) and extracellular signal-regulated kinases (ERK) 1/2 in ischemia. The aim of this thesis was …
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Pre-clinical Targets for Ischemic Brain Injury
… in the cerebral blood flow which results in ischemia. Injury to the myelinated axons located in white matter is observed in ischemic injuries but is generally underappreciated. Research has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury …
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Vascular receptor changes in ischemic stroke
… receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor regulation. For functional studies of cerebral arteries, sensitive myographs were …
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Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype
… is a widely used experimental technique to model focal ischemia in rodents. Various neurobehavioral tasks have been developed to assess the motor and cognitive dysfunctions associated with MCAO in rodents, and these studies have shown deficits related to impaired long-term sensorimotor function, …
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Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… neurons in several animal models of cerebral ischemia. Therefore, to decipher the significance of the ER stress apoptotic response, we investigate the role of ATF4-CHOP signaling pathway in ischemic neuronal injury. Ischemic stroke results from a transient or permanent reduction in cerebral …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… cell death [1, 4, 15, 16]. The effect of ischemia on brain cells results not only in loss of structural integrity of brain tissue but affects also blood vessels, partly through the activation of inflammatory events and excess production of vasoconstrictor substances and increased receptor …