Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"focal adhesion kinase"”.
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
… known integrator of cell-ECM signaling, namely, focal adhesion kinase (FAK), during oligodendrocyte morphological maturation in vivo and in vitro. Conditional and inducible FAK-knockout mice (Fakflox/flox: PLP/CreERT mice) were generated to observe the effect of FAK loss on myelination in vivo. …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
<p>Tyrosine-phosphorylated FAK is required for the hypertrophic response of cardiomyocytes to growth factors and mechanical load, but the role of FAK serine phosphorylation in this process is unknown. Endothelin-1 (ET-1; 1-100nM, 2-30min) and other hypertrophic factors induced a time- and …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
<p>Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that mediates interactions between the extracellular matrix and intracellular signaling pathways critical in promoting numerous cellular functions including adhesion, proliferation, survival and migration. Most FAK functions result …
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Integrin alpha(v) and Focal adhesion kinase - promising targets to limit smooth muscle cell migration
… Proteins, das mittels Immunpräzipitation als “focal adhesion kinase” (FAK) identifiziert wurde. Die erhöhte PTyr zeigte sich auch am Tyrosinrest FAK Tyr-397, der Autophosphorylierungsstelle der Kinase. Die erhöhte PTyr von FAK war abhängig von der Stimulation durch VN und nicht zu beobachten, …
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Targeting integrin alpha 5 and focal adhesion kinase to overcome azacitidine resistance in higher risk myelodysplastic syndromes
… an integrin alpha 5 blocking antibody or a focal adhesion kinase inhibitor could overcome azacitidine resistance. After establishing an effective dose of the focal adhesion kinase inhibitor, GSK2256098, I demonstrated that these doses were not toxic to healthy haematopoietic stem and …
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A role for focal adhesion kinase in the contraction of gastric fundus smooth muscle evoked by cholinergic neurotransmission
Integrins are trans-membrane receptors that form focal contacts and mediate the attachment of the smooth muscle cell cytoskeleton to the extracellular matrix. Focal adhesion kinase (FAK) regulates the recruitment and assembly of focal adhesion proteins. It has been established that integrin …
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Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy
… engagement and growth factor receptor tyrosine kinase (RTK) activation. Pairs of rat mesenteric arteries were pressurized to 90 mmHg (control), and then one was raised to 140 mmHg for 1, 3, 5 or 10 minutes. Western blotting using phosphorylation-specific antibodies revealed that …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
… aggrecan, but not type II collagen. Furthermore, focal adhesion kinase (FAK) was found to be an upstream mediator of CCN2 expression and the absence of FAK promotes the process of chondrogenesis. Therefore, CCN2 is required for early chondrogenic events, downstream of FAK and is responsible for …
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… identified as a downstream target for various kinases but effects of growth factors, which play a crucial role in the development and progression of cancer, on DLC1 have not yet been elucidated. We have identified a novel pathway involving the concerted action of Ras/Mek/Erk pathway, Focal …
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Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells
… remain elusive. In this study we show that focal adhesion kinase (FAK) regulates Sox2 expression and H3K9 de-methylation through cell division control protein 42 homolog (Cdc42). In comparison to control melanoma cells, TRCs exhibit low FAK and Cdc42 expression. Overexpressing FAK or Cdc42 …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… of breast cancer. Integrin-mediated adhesion and signaling are crucial for mammary tumorigenesis and tumor progression, in which focal adhesion kinase (FAK) - Src family kinases (SFKs) serves as a hub to relay the mechanical cues from the ECM. We have investigated the mechanisms …
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Dual Assembly Nanoparticles Achieve Sustained Silencing of Znf304: A Novel Transcription Factor For Β1 Integrin
… β1 integrin, which subsequently regulates Src/focal adhesion kinase and paxillin and prevents anoikis. Targeting ZNF304 using small interfering RNA (siRNA) reduces cell survival, anoikis and migration in vitro. A novel dual assembly nanoparticle system (DANP) was designed for in vivo delivery …
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Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
… metastasis in patients. Proteins recruited at adhesion complexes, known as the adhesome, are involved in multiple mechanisms which control cancer cell behaviour. Here, we used a proteomic and network analysis approach to perform a global assessment of functional molecular units associated with …
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LRRK2 Regulates Actin Dynamics in ADP-Treated Microglia
… immunoprecipation assay, LRRK2 interacted with focal adhesion kinase (FAK), a protein that regulates the adhesion and migration of cells. LRRK2 and FAK were co-localized with ruffles when microglia actively moved. The overexpression of LRRK2 reduced the phosphorylated FAK levels compared with …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… to prevent metastatic relapse. Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and progression and describe a novel mechanism by which it facilitates immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon …
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TIS21 inhibits cell migration and invasion
… was correlated with downregulation of focal adhesion kinase (FAK) tyr576 and tyr925 residues phosphorylation. However, tyr397 which was autophosphorylation site was not influenced by TIS21 expression. c-Src phosphorylation which was upstream of FAK was not influenced by TIS21, however, …
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Computational modeling of protein-biomolecule interactions with application to mechanotransduction and antibody maturation
… a paxillin fragment bound to the FAT domain of focal adhesion kinase (FAK) revealed several structural mechanisms responsible. Second, we used computational methods to design individual mutations computed to improve binding affinity of an antibody-small molecule complex with relevance to cancer …
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Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… to inhibitors of the mitogen-activated protein kinase (MAPK) pathway, a frequent target for melanoma treatment. Rac1P29S bypasses the MAPK axis through a mechanism that necessitates cell-matrix attachment, however, does not depend on integrin-mediated focal adhesion assembly and focal adhesion …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
… involving three repeated sequential steps: adhesion, proteolytic degradation of the basement membrane and other extracellular matrixes (ECMs), and cell migration. These three steps are linked and interdependent. For example, cell adhesion to the ECM triggers a series of signal transduction …
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