Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"foam cells"”.
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Investigating iPSC-Derived Macrophage Stimulation with Oxidised Low-Density Lipoprotein as an Effective In Vitro Model of Foam Cells in Atherosclerosis
… Macrophages and vascular smooth muscle cells (VSMCs) in the arterial wall respond by ingesting large quantities of the modified lipoproteins, such as oxidised low-density lipoproteins (oxLDLs), which are then metabolised to release cholesterol and cholesterol esters for use or recycling. …
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Macrophage Activation Profile and Phenotype Are Regulated by Metabolic Pathways and Are Altered by Diabetic Conditions
… accumulating lipids and becoming proinflammatory foam cells. In chapter three we demonstrate that diabetes enhanced the expression of CD36 and SR-A and the accumulation of cholesteryl ester and acetylated-LDL in primary mouse macrophages to form foam cells similar to those found in atherosclerotic …
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SERUM ANTI-PHOSPHORYLCHOLINE AND ANTI-CARDIOLIPIN CONCENTRATIONS FOLLOWING PERIODONTAL SCALING AND ROOT PLANING
… and engulf oxidized-LDL (oxLDL) to form foam cells. Knowing that certain antibodies directed against bacterial antigens such as phosphorylcholine (PC) and cardiolipin (CL) show opsonizing cross-reactivity with oxLDL it can be proposed that there is a link between immune responses to …
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Development of in vivo Raman spectroscopy of atherosclerosis
… adipocytes, crystals containing 3-carotene, foam cells, necrotic core, and smooth muscle cells. This model prospectively classifies atherosclerotic tissue into three categories: non-atherosclerotic, non-calcified plaque, and calcified plaque, with >94% accuracy. Furthermore, this model has …
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Development of multimodal spectroscopy for the detection of vulnerable atherosclerotic plaques
… a thin fibrous cap, necrotic core or superficial foam cells, and thrombus.
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Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function
… giving rise to an increased propensity for foam cell development. Importantly, both chronic inflammation and the generation of foam cells are correlated with the pathogenesis of atherosclerosis and therefore may play an important role in diabetes-accelerated atherosclerosis.
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Colony Stimulating Factor-1 Receptor (CSF-1R) Expression, Degradation, and Signaling in Lipid-Laden Macrophages
… in CSF-1 signaling and related pathways in foam cells remain poorly investigated. Lipid-laden macrophages were formed through exposure of murine bone marrow derived macrophages to 100 μg/ml acetylated LDL for 24 h. Non-LDL treated macrophages were grown in parallel for each experiment and …
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Development of a novel in vitro model to study the tryptic : endothelial cells, monocytes and flow
… seeded with a confluent monolayer of endothelial cells co-cultured with THP- 1 monocytes under flow. We used the model to draw biological insight from endothelial:monocyte co-cultures under flow. We found that monocytes preferentially accumulate on endothelial monolayers exposed to atheroprone …
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High Fat Diet Effects on Erythrophagocytosis and MCP-1 Levels in Mice
… damage and subsequent inflammation. Immune cells, such as monocytes, respond to chemokines and differentiate into macrophages, engulfing oxidized lipids, and forming foam cells within the vessel wall. Red blood cells (RBC) are known to bind chemokines through the Duffy antigen receptor for …
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Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… of cholesterol-laden macrophages, called foam cells. Uncontrolled inflammation in plaques makes them “unstable” and vulnerable to rupture and thrombosis, which causes complications, such as myocardial infarction (MI) in the case of atherosclerotic coronary artery disease (CAD). Current …
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The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… space where they develop into macrophage foam cells and give rise to atherosclerotic plaques. Elevated numbers of blood monocytes are strongly associated with coronary heart disease likely because increased numbers of monocytes drive their infiltration into atherosclerotic plaques. Studies …
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Modification of Low Density Lipoprotein and the Effects of Modified Low Density Lipoproteins on the Endocytic and Secretory Repertoire of the Macrophage
… isolated human monocytes (2 x 10<sup>6</sup> cells per ml), with or without phorbol myristate acetate (100 ng/ml) to trigger the respiratory burst, did not oxidize LDL in the TBA assay, despite producing large amounts of reactive oxygen intermediates. EDTA-LDL, CDP-LDL, and acetoacetylated LDL …
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Pathogenesis of experimental tuberculosis in guinea pigs
… within or between susceptible hosts. If infected cells within the granuloma die, intracellular bacteria are released and become entrapped in an extra-cellular microenvironment where they persist for long periods of time protected from drug therapy and the host immune response. The mechanism …