Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"foam cell formation"”.
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Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… of cholesterol-laden macrophages, called foam cells. Uncontrolled inflammation in plaques makes them “unstable” and vulnerable to rupture and thrombosis, which causes complications, such as myocardial infarction (MI) in the case of atherosclerotic coronary artery disease (CAD). Current …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… pneumoniae</em> is an obligate intracellular bacterial pathogen that induces macrophage foam cell formation, a hallmark of early atherosclerosis, in the presence of low-density lipoprotein (LDL). Toll-like receptors (TLRs) play a central role for macrophages to detect pathogens and …
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Investigating iPSC-Derived Macrophage Stimulation with Oxidised Low-Density Lipoprotein as an Effective In Vitro Model of Foam Cells in Atherosclerosis
… at predilection sites for atherosclerotic plaque formation involves the retention and modification of lipoprotein particles. Macrophages and vascular smooth muscle cells (VSMCs) in the arterial wall respond by ingesting large quantities of the modified lipoproteins, such as oxidised low-density …
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… of atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress is considered the primary source of endothelial cell (EC) senescence in vivo. EC senescence leads to abnormal proliferation of vascular smooth muscle cells, …
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Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… a fundamental guiding principle underlying many cellular processes. By creating and stabilizing diffusional barriers, the cytoskeleton can precisely regulate the association or dissociation of molecules in both time and space, ultimately dictating the signalling output of a cell. In this …
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Platelet adhesion in atherogenesis
… adhesion may initiate atherosclerotic lesion formation. The proposed research aimed to investigate this by seeing whether platelet adhesion occurred, directly or via leukocytes, to the endothelium in diabetic conditions. Diabetic-like conditions were chosen because an accelerated rate of …
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Studies of Atherosclerosis in Systemic Lupus Erythematosus
… that while there was no in vitro difference in foam cell formation or clearance of apoptotic cells, there was increased TNFalpha, IL-12p40, IL-6, MCP-1, and IL-10 gene expression in response to six hours of 100 ng/ml of LPS treatment independent of 1 x 10 ^ -9 M 17beta-estradiol treatment. Our …
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Characterization of zein extracted from beer solids, a coproduct of dry-grind ethanol
… applications as tissue scaffolding, to enhance cell spreading and viability. Coproducts of corn-to-ethanol processing remain potential sources of zein. Distillers’ wet grains (DWG) a coproduct of dry grind ethanol contain about 40% (db) protein, where 50% of the protein is zein. Attempts to …