Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"flutamide"”.
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The Encapsulation and Release of Flutamide Using Poly (ε-Caprolactone) Microspheres
… An example is anti-androgenic drugs such as flutamide (FLT) used in hormonal therapy. The disadvantages to FLT are that it has low bioavailability in oral formulations, low aqueous solubility, compliance issues and rapid first pass metabolism. Recent advances in novel drug delivery have led …
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Effects of exogenous androgens on parental care behaviour in male bluegill sunfish (Lepomis macrochirus)
… males with testosterone, 11-ketotestosterone or flutamide, an androgen receptor blocker, and tested their nurturing behaviour and aggressiveness towards a brood predator. Males implanted with 11-ketotestosterone were 64% more aggressive and 71% less nurturing than controls. In contrast, males …
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Importância da atenção farmacêutica na adesão ao tratamento com flutamida em um hospital oncológico.
… adherence to treatment with oral antineoplastic flutamide in patients at an oncology hospital in João Pessoa. Methods: A descriptive cross-sectional and prospective study was conducted through questionnaires in order to examine adherence to therapy with flutamide, which used the indirect test …
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Sex Determination And Differentiation In The Common Snapping Turtle - A Reptile With Temperature-Dependent Sex Determination
… dihydrotestosterone (DHT), the anti-androgen, flutamide, or a vehicle (ethanol) control. Whole mount in situ hybridization and immunohistochemistry were used to determine the effect of the treatments on sex differentiation of the male reproductive tracts. Quantitative real-time PCR was used to …
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Crystallography of Pharmaceuticals: Ways to improve efficiency and assessing the fragment-based approach for enhanced polymorph discrimination
… have considered four organic systems: cocaine, flutamide, AZD8329, and flufenamic acid. After, we will briefly discuss the fragment-based approach for calculating NMR parameters and how this approach allows us to include relativistic effects at the spin-orbit level of theory, which we hope can …
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Small molecule inhibitors of steroid receptors for breast and prostate cancer
… of classical AR antagonists, bicalutamide or flutamide. Additionally, CPIC at nanomolar concentrations, but not bicalutamide, disrupts the amino-carboxyl (N/C) terminal interaction of AR, which is crucial for optimum androgen-mediated AR signaling. Also described here is a novel …
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Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… morphine or the androgen receptor antagonist, flutamide, attenuated ET-1 induced sensitization in males. For females, ET-1 exposure resulted in local de-sensitization and dermatome specific sensitization, local up-regulation of ETB receptor expression and changes in ETB:ETA receptor ratio. …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
Flutamide (FLT) is an anticancer agent used in the treatment of prostatic carcinoma. FLT amorphous solid dispersions (SDs) and solid lipid nanoparticles (SLNs) were prepared to overcome limited solubility. Investigation of drug-polymer and drug-lipid miscibility was carried out to enhance drug …
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Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats
… finasteride (5a-reductase inhibitor), flutamide (androgen receptor antagonist), or vehicle (VEH). Higher CORT concentrations after restraint were found in P45 than in P75 only among VEH rats. Among P45 rats, CORT levels were higher in VEH than in fadrozole-treated rats only. Among P75 …
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The Role of a Membrane Androgen Receptron in the Brain
… these signaling pathways is AR dependent, since flutamide blocked this effect. In contrast to the intracellular receptor, we concluded that DHT-BSA (membrane impermeant form of DHT) binds to DHT displaceable sites on the plasma membrane. Also, treatment with DHT-BSA in the C6 cells resulted in a …
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Assessing Brook Stickleback (Culaea inconstans) as a bioindicator for endocrine disrupting compounds in aquatic environments
… to MT at 500 ng/L and an anti-androgen (flutamide; FL) at 25, 150 and 250 µg/L for 14 days (sampled at 4 and 14 days) to validate this bioassay for the evaluation of anti-androgens using the same endpoints as in the previous two experiments. In females, exposure to MT increased spiggin …
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Role of GnIH and GnRH in Paracrine Control of Gametogenesis in Zebrafish (Danio rerio)
… cell production was blocked in the presence of flutamide (FLU) androgen receptor antagonist. A number of transcripts were also measured to better understand zGnIH mechanisms of action on zebrafish spermatogenesis. Further analysis of paracrine actions of zGnIH on earlier stages of …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… in the β-catenin cKO embryos after treating with flutamide, an anti-androgen drug. This result ruled out the ectopic androgen production from being responsible for germ cell loss. On the other hand, the number of germ cells was restored in the Wnt4 and Inhbb double KO indicating that Inhbb was the …
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Role of androgens in testicular development and dysgenesis
… (DBP, testosterone propionate; TP) or action (flutamide, DMBA) or to induce intrauterine growth restriction (dexamethasone), another risk factor for TDS. The aforementioned endpoints were analysed in fetal testes and related to testicular testosterone levels and peripheral androgen action …
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Structural Basis for the Molecular Recognition of Androgen Receptor Ligands: Insights Guiding the Design and Synthesis of Novel Nonsteroidal Ligands
… <p>The binding modes of several hydroxyflutamide-like nonsteroidal ligands for the AR were investigated. These nonsteroidal ligands were docked into one of our AR models with FlexX, followed by refinement of the initial AR-ligand complexes with molecular dynamics simulations. Asn705 is …