Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"fluoxetine"”.
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FLUOXETINE AS A NOVEL TREATMENT TO ATTENUATE CISPLATIN-INDUCED COGNITIVE IMPAIRMENT
… cognitive impairment (CRCI). Fluoxetine (FLX) is a selective serotonin reuptake inhibitor widely used in patients with anxiety and mood disorders. Published studies report that FLX could sensitize cancer cells to chemotherapy treatment and assist in attenuating CRCI. The aim of …
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Network mechanisms underlying susceptibility to helplessness and response to the antidepressant fluoxetine
Depression and post-traumatic stress disorder are common psychiatric comorbidities related to stress. These conditions are frequently treated with antidepressants such as selective serotonin reuptake inhibitors (SSRI’s). However, there are individual differences in susceptibility to stress-induced …
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Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol
… quantify acute electrophysiological effects of fluoxetine and ethanol. Spontaneously active frontal cortex cultures showed highly repeatable, dose-dependent sensitivities to both compounds. Cultures began to respond to fluoxetine at 3 µM and were shut off at 10-16 µM. EC50s mean ± S.D. for spike …
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Pattern Analysis of Response to Acute Fluoxetine Treatment in the Prediction of Relapse in Children and Adolescents
… between Quitkin response patterns during acute fluoxetine treatment and subsequent risk for relapse during randomized placebocontrolled continuation. A total of 168 children age 7 to 18 meeting DSM criteria for MDD first entered 12 weeks of acute treatment on open-label fluoxetine 10.40 mgs with …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… our lab demonstrated the combination of chronic fluoxetine (FLX) and acute ketamine treatment decreased fear response in a contextual fear paradigm in male C57/BL mice. In rodents, fear conditioning (FC) is commonly used in the literature to induce behaviors related to PTSD. The mammalian central …
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Effects of Alterations in Monoamine Levels on Conditioned Taste Aversions in the Rat.
… Use of the specific serotonin uptake inhibitor fluoxetine HCl in the present studies allowed for more controlled manipulation of serotonergic activity.Experiment 1 compared the effectiveness of fluoxetine HCl and the noradrenergic uptake inhibitor desipramine in disrupting a LiCl-based …
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Pharmacological fMRI on the effects of Fluoxetine on functions of Working Memory, Impulsiveness and Cognitive Flexibility in boys with Attention Deficit Hyperactivity Disorder and boys with Autism Spectrum Disorder
… Serotonin modulates these functions and Fluoxetine has positive clinical effects in these disorders. <br/>Functional magnetic resonance imaging was used to scan 22 ADHD and 22 ASD boys, under placebo or an acute dose of Fluoxetine, in a double-blind, placebo-controlled, randomised design, …
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Environmental enrichment and serotonergic alterations on depressive-like states in rats
… of the commonly prescribed antidepressant drug, fluoxetine. In the present study, locomotor activity and FST performance were measured after 30 days of rearing in enriched (EC), standard (SC), and isolated (IC) conditions. Results showed that regardless of the significant effect of fluoxetine on …
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The Role of the Serotonergic Neurotransmitter System in the Development and Treatment of Affective Disorders
… data from the Allen Brain Atlas. In postnatal fluoxetine treated mice, we report alterations at the anatomical, electrophysiological, and transcriptional levels. Serotonergic innervation of the prefrontal cortex and hippocampus was reduced by fluoxetine treatment, consistent with the …
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Residual Symptoms in Pediatric Depression after Acute Pharmacological Treatment
… Graham J. Emslie investigating the efficacy of fluoxetine 20 mg/day for 8 weeks in children and adolescents with non-psychotic depression. Evaluating the patients using the more stringent criteria of remission in responders, showed that 64% of fluoxetine treated patients, and 56% of placebo …
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Microplastics as a vector for micropollutants in aquatic environments.
… (ibuprofen, carbamazepine, venlafaxine, fluoxetine, and ofloxacin) were selected to evaluate their interaction with microplastics. The selected micropollutants were placed in contact with microplastics in a range of pollutant combinations (in mixtures and individually). Later, fluoxetine …
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Effect of Rat Strain Stereotactic Coordinates on Infarct Volume
… study was a combination of the pharmaceuticals Fluoxetine (SSRI), Simvastatin (statin), and ascorbic acid (Vitamin C). 51 adult rat subjects (10-12 months of age; 44 Sprague Dawley, 7 Long Evans) were given a combination of the drugs for 31 days. Drugs were given through voluntary oral …
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Optimisation of protein and lipid extraction from low-value fish sources and investigation of high-value applications
… own and in conjunction with the anti-depressant fluoxetine, as a treatment for depressive and anxiety-like symptoms associated with early life stress. The maternal separation model of early life stress was used in male Sprague-Dawley rats to test these treatments. Maternally separated rats showed …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… to assess the effects of the classic SSRI fluoxetine on 5-HT1A receptor-mediated autoinhibition. We conducted these experiments in mice expressing the light-sensitive ion channel Channelrhodopsin (ChR) in 5-HT neurons to facilitate their unambiguous identification and achieve precise …
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The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women
… rats. Chapter 4 compared the effects of chronic fluoxetine (an SSRI, the first-line pharmacological treatment for anxiety disorders) in nulliparous versus primiparous rats. Fluoxetine produced anxiogenic-like effects in nulliparous rats, but not primiparous rats; in contrast, fluoxetine reduced …
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The Effect of SSRIs on Adult Human Visual Cortex Plasticity. Do SSRIs Affect learning?
… vision were randomized to a three-week course of fluoxetine or placebo. During drug administration, participants were trained on a motion discrimination task at a fixed motion direction. Learning was assessed for the trained motion direction and an untrained direction with and without a single …
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Chemometric Analysis of Multivariate Liquid Chromatography Data: Applications in Pharmacokinetics, Metabolomics, and Toxicology
… of p-methoxyrnethamphetamine (PMMA) and fluoxetine by the CYP2D6 enzyme using a steady-state (SS) approach and a new general enzyme (GE) screening method. For PMMA, the SS experiment resulted in a CLint of 2.7 ± 0.2 µL pmol 2D6-1min-1 and the GE experiment resulted in a CLint of 3.0 ± 0.6 …
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Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants
… be part of the mode of action of different ADs, fluoxetine, desipramine and agomelatine. Moreover, in order to assess the time course of ADs effects, treatments were performed for various time lengths (3,7 or 21 days). Rat hippocampal miRNome expression was investigated by means of TaqMan Rodent …
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An Examination of Affective Blunting in Rodents
… study looked to examine the effects of chornic fluoxetine (0.16g/L) administration on pre-test and post-test performance of a light aversion task and a sucrose preference test. The light aversion task presents subjects with a bright aversive light which can be terminated by a head-entry into an …
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NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)
… Studies from our lab have shown the role of fluoxetine (selective serotonin-reuptake inhibitor) in preventing seizure-induced respiratory arrest (S-IRA) in DBA/1 mouse model of SUDEP, but the neuronal networks mediating S-IRA and the brain structures involved in the fluoxetine-mediated …
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