Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"fluorine-18"”.
-
Development of Fluorine-18 Halofluorination and Fluorine-18 Fluoride Ion Displacement Reactions for the Synthesis of Fluorine-18 Labeled Radiopharmaceuticals (Spiperone, Spiroperidol, N-Alkylation, Radioactivity)
Two fluorine-18 labeling methods, ('18)F halofluorination and ('18)F fluoride ion displacement reactions, have been developed to assess their potential for labeling molecules with the positron-emitting radionuclide fluorine-18 at the no-carrier-added level.
-
Novel applications of fluorine-18 labelled radiotracers in cardiovascular disease
… immediately by PET/MR. Valve and coronary 18F-fluoride uptake were evaluated independently. Both standard (Dixon) and novel (radial GRE) MR attenuation correction (AC) maps were validated against PET/CT with results expressed as target-to-background ratios (TBRs). Visually, aortic valve …
-
I. Facile preparation of ortho-fluorophenols from non-aromatic precursors and investigation of applications to fluorine-18 labeling II. Resin-supported silyl ester precursors for kit-like radiolabeling with fluorine-18
… commonly used positron-emitting radionuclides, fluorine-18 has a number of preferred characteristics which are, 1) longest half-life, 109 minutes, 2) lowest maximum energy and 3) purest mode of decay. However, F-18 radiolabeling method is still underdeveloped, and thus, practical radiosyntheses …
-
Synthesis and evaluation of fluorine-18 labeled androgens as in vivo imaging agents for prostatic cancer using PET
In order to develop androgen receptor (AR) based probes for in vivo imaging of prostatic cancer using positron emission tomography (PET), four pairs of 16$\beta$- and 16$\alpha$-fluoro androgens, as well as two 20-fluoro androgens have been synthesized. The fluorination was achieved mainly by …
-
Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain
… labeled with the positron-emitting radionuclide fluorine-18 (t$\sb{1/2}$ = 110 min) by fluoride ion (n-Bu$\sb4$N$\sp{18}$F) displacement of a 16$\beta$-trifluoromethanesulfonate (triflate) derivative of the corresponding estrone 3-triflate, and purification by HPLC. That sequence has been used to …
-
Design, Synthesis and Biological Properties of Fluorinated Estrogens, Progestins and Androgens, Potential Imaging Agents for Receptor-Positive Mammary and Prostate Tumors (fluorine-18)
… synthesized in the development of a potential fluorine-18 radiolabel useful as a means of quantifying estrogen receptor in receptor-positive mammary tumors. The affinities of the compounds for estrogen receptor were measured using competitive radiometric binding assays and …
-
Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… breast carcinoma. Molecular probes, such as fluorine-18 radiopharmaceuticals, bivalent ligands, and affinity labels, provide information toward a better understanding of ER localization, structure, and function. We have prepared two fluorinated analogs of 2-oxohexestrol as potential …
-
I. Synthesis of Myocardial Imaging Agents for Diagnosis of MCAD Deficiency. II. Synthesis of [fluorine-18] Fluoroaryl Estrogens as Receptor Based Tumor Imaging Agents for Breast Cancer
The synthesis of a (fluorine-18) fluoroaryl estrogen in no-carrier-added form requires the use of ($\sp{18}$F) F$\sp-$. A great amount of effort has been made toward incorporation of ($\sp{18}$F) F$\sp-$onto an electron-rich aromatic ring, but none have found general application. Several strategies …
-
THE EXPLORATION OF THE VALIDITY OF QUANTITATIVE 2-DEOXY-2-[FLUORINE-18] FLUORO-D-GLUCOSE (18F-FDG) POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY (PET/CT) TO ASSESS LUNG INFLAMMATION
… of trace quantities of a radioactive tracer. 18F-FDG is the most widely available tracer and in several small studies has been used to investigate diffuse lung diseases such as chronic obstructive pulmonary disease (COPD). These studies rely on quantification of the PET image. Static …
-
I.~fluorine-18 Labeled Corticosteroids and Progestins for Receptor-Based Imaging of the Brain and of Breast Tumors. II.~Synthesis and NMR Spectrum of (carbon-13(18))-Meso-Hexestrol
… positron emission tomography and an appropriate fluorine-18 labeled ligand. We have prepared fluorinated analogs of six natural and synthetic corticosteroids as potential diagnostic imaging agents for Alzheimer's dementia. Four of these ligands have been prepared in fluorine-18 labeled form …
-
Part I. Aromatic Fluorinations for Fluorine-18 Labeling of Estrogens. Part Ii. Bromodesilylation-Potential Method for Regiospecific Radiobromination of Aromatic Systems. Part Iii. Synthesis of Isohexestrol and Isohexestrol Derivatives
… investigated as methods potentially suitable for fluorine-18 labeling of estrogens. The aryl triazene method gives moderate yields in many systems, but fails with ortho methoxy or methanesulfonyloxy groups. The aryl azide method gives good yields of p-fluoroanilines, which can be deaminated …
-
Late stage 18F-difluoromethylation of N-heteroaromatics
… methodology for the late stage addition of CHF18F to N-heteroaromatics for PET imaging. This methodology proceeds via C-H activation, under flow photoredox conditions. The 18F-difluoromethylation relies on the use of a new 18F-difluoromethylating reagent derived from the Hu’s reagent. This …
-
I. Molecular Probes for the Progesterone Receptor. II. Design and Synthesis of a Rigidly Constrained Peptidomimetic as a Potential Beta-Turn Mimic. III. Isolation and Characterization of Novel Ion Channel Modulators From Commercial Phenol Red Preparations
… pregn-4-ene-3,20-dione (34) was prepared in fluorine-18 labeled form, and evaluated for its in vivo biodistribution in rats. The fluorine-18 labeled progestin showed selective uterine uptake, which was blocked by coinjection of a saturating dose of the unlabeled progestin ORG 2058. Metabolic …
-
I. Development of novel silicon precursors for rapid and efficient radiofluorination reactions: synthesis and biological evaluation of a 18f-labelled estrogen dendrimer conjugate II. Other studies on 18f-labelled estrogens
… beyond the most commonly used PET tracer, [18F]fluorodeoxyglucose, including the use of large, sensitive biomolecules such as peptides and antibodies, which may be of considerable clinical importance. However, the available methodology associated with PET isotope incorporation, specifically …
-
Competition in the radioisotopes market: evaluation and analysis of drivers which affect mo-99 market share
… Lutetium 177 non-carrier-added (Lu-177 n.c.a.) & Fluorine-18 (F-18)), that are used as Active Pharmaceutical Ingredients (APIs) for the manufacture of radiopharmaceuticals. The most prevalent diagnostic radioisotope among these fission isotopes, Mo-99, which is used to create …
-
Synthesis and biological evaluation of 11beta-substituted and 7alpha-substituted estradiol analogs for the study of estrogen responsive breast tumors
… binders than the fluoroalkoxy ones. All of these fluorine-substituted estrogens were prepared in fluorine-18 labeled form, with high radiochemical purity and at effective specific activities (415-1362 Ci/mmol), adequate for biodistribution studies. In immature female rats, five of the six …
-
Targeted Imaging Agents for Detecting Tumour Cell Death following Therapy
… protein (C2Am) has been derivatised with a fluorine-18 containing maleimide for imaging tumour cell death in a xenograft murine advanced colorectal cancer. A one-pot, two-step automated synthesis of N-(5-[18F]fluoropentyl)maleimide using a GE TRACERlab FXFN automated module (within 58±5.8 …
-
Microfluidic modules for pre-concentration of [¹⁸F]fluoride in positron emission tomography (PET) radiotracer synthesis
… of several other PET radionuclides makes fluorine-18 (¹⁸F) the most predominant in the fields of oncology and neuroscience. The aim of the Radiochemistry On Chip (ROC) project was to develop such an integrated lab-on-chip device and, in particular, here results for on-chip …
-
Targeting Inflammation in Atherosclerosis: The Role of Low-dose Interleukin 2 in Acute Coronary Syndromes
… between the groups as measured by 2-Deoxy-2-[fluorine-18] fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). We demonstrated that low-dose IL-2 reduced arterial inflammation in patients presenting with ACS. There was a strong correlation between the …
-
Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… were developed to produce [11C]Quin C1 and [18F]Quin C1-click-F, two potential FPR2-targeting PET radioligands identified through collaboration with Imperial College London. Radiotracer [11C]Quin C1 was produced with decay-corrected radiochemical yield (d.c.RCY) (decay corrected to the start …
Page 1 of 2