Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"fluorescent activated cell sorting"”.
-
Antibody engineering for tumor immunotherapy
… antigen. CEA is also quite stable, with a cell-surface shedding half-life of approximately 7 days. Directed evolution methodology has been utilized to design an antibody fragment with properties that would improve tumor retention. Specifically, antibody engineering methods were used to …
-
Characterization of subtypes of precursor cells in the developing central nervous system
The role of radial glial cells as guides for migrating neurons is well established, whereas their role as precursor cells is less understood. Here we examined the composition of radial glial cells and their proliferation in the mouse telencephalon during development. We found that almost all radial …
-
Molecular mechanisms of neuronal homoeostasis in vivo
… the change in electrical properties of granule cells in the dentate gyrus and pyramidal cells in CA1 caused by expression of Kir2.1. I show that the excitability of neurones expressing Kir2.1 was reduced compared to control neurones. By 2 weeks after virus injection the neurones showed …
-
Preclinical Models to Identify Molecular Drivers of Metastasis in Paediatric Musculoskeletal Cancer
… progression and pathogenesis. Several MS cancer cell lines have been characterised in vitro and in vivo, but a clinically relevant mouse model of musculoskeletal tumors model with spontaneous metastasis has not been validated. The aim of this thesis research was to develop a robust experimental …
-
Stage-Specific Multiomic Analysis of Human Erythroid Differentiation
Significance: Reduced red blood cell (RBC) production resulting in anemia is a common symptom of many diseases. RBC transfusion and erythropoiesis-stimulating agents (ESAs), primarily erythropoietin (Epo) and its analogs, are major treatments for anemia, but often lead to organ damage and/or ESA …
-
St John's Wort photomedicine for Melonoma
… light and molecular oxygen. Following cellular uptake of the photosensitizer, its activation by light produces reactive oxygen species in the presence of oxygen. The resulting cytotoxic oxidative stress elicits cancer cell death by various mechanisms including apoptosis, necrosis and …