Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"fluid shear stress"”.
-
Fluid Shear Stress Effects on Cancer Metastasis
… yet it remains a poorly understood phenomenon. Fluid shear stress is common to all metastatic events but its effects on circulating tumor cells (CTCs) remains a mystery. It is known that shear stress can act either directly, causing membrane rupture and cell death, or by altering cell phenotype …
-
Glycocalyx acting as a mechanotransducer of fluid shear stress
It is widely recognized that fluid shearing forces acting on endothelial cells (ECs) have a profound effect on EC morphology, structure and function. Recent investigations in vivo have indicated the presence of a thick endothelial surface layer, also called the glycocalyx, with an estimated …
-
A cell-based sensor of fluid shear stress for microfluidics
Fluid flow is an essential feature of every microsystem involving cell handling, culture or sorting. The particular application determines the relevant flow rates used in a device. Flows inevitably generate fluid shear stress (FSS) that may cause undesirable physiological cell stress. Simple assays …
-
The dynamic response of vascular endothelium to fluid shear stress in vitro
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1983.
-
Functional and molecular characterization of the vascular endothelial response to fluid shear stress
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1994.
-
The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… cells are the interface between hemodynamic fluid flow and vascular tissue contact. They actively translate physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased conditions. For …
-
Evaluating the Effects of Fluid Shear Stress on Ovarian Cancer Progression and Metastatic Potential
… cells to biophysical forces, particularly fluid shear stress (FSS). These biomechanical forces, only recently identified as a hallmark of cancer, induce rapid signaling events in attached and aggregated cells, a process termed mechanotransduction. The cellular responses to these forces and …
-
Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… stimulation of osteoblasts and osteocytes by fluid shear stress further enhanced expression of osteocalcin when Src activity was inhibited. Importantly, fluid shear stress stimulated an increase in nuclear Src activation and activity. The mechanism by which Src participates in attenuating …
-
Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
… frictional force exerted by the flowing blood, fluid shear stress (FSS). The hemodynamics dictating this force determine, to a large extent, the likelihood that a given region of a blood vessel will develop atherosclerotic plaque. In linear arterial segments, VECs are exposed to high laminar …
-
Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells
… needed to nourish the embryo. At this stage, fluid shear stress of blood flow is the principal mechanical force that drives further differentiation into endothelial cell (EC) phenotype.</p> <p>It has been shown that shear stress plays a critical role in promoting endothelial cell (EC) …
-
In Vitro Regulation of Ptgs2 and Nos3 Expression in Clonal Osteogenic Cells Following Pulsatile Fluid Flow
… The first hypothesis was mechanically induced fluid flow through the lacuno-canalicular system stimulates osteocytes by fluid shear stress. When stimulated, these osteocytes then activate adjacent osteoblasts. The magnitude of fluid shear stress to which bone cells are exposed, directly …
-
Development of a methodology for applying shear stress to suspended mammalian cells
Fluid shear stress is a typical mechanical stimulation that mammalian cells are exposed to both in vivo and in vitro. In in-vivo conditions, the stress exists in the blood and lymphatic vessels as well as other body fluids transmission paths, including the tissue interstitial flow, the bone marrow, …
-
Development of a novel uncovered stent system for the management of complex aortic aneurysms
… types. - Solid-to-solid interaction and one-way fluid-solid interaction (FSI) analysis was performed based on patient-specific computer tomography angiography (Chapters 5&6). Structural stress concentrations were observed within the landing zones, which increased with the number of stents …
-
Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
To test the hypothesis that wall shear stress generated by blood flow may regulate endothelial cell expression of blood clot dissolving proteins or vasoactive proteins, an in vitro perfusion system was used to expose human umbilical vein endothelial cell monolayers to well defined, laminar fluid …
-
Effect of shear stress on surface membrane potassium ion permeability of calf pulmonary artery endothelial cells (Potassium ion)
This study aims to determine the effect of shear stress on membrane potassium (K$\sp+$) permeability in vascular endothelial cells. Cultured monolayers of calf pulmonary artery endothelial cells, preloaded with $\rm \sp{86}Rb\sp+$, were subjected to different levels of fluid shear stress in the …
-
Effect of Prostaglandin E2 on Mechanical Stresses Applied by MC3T3-E1 Osteoblast-like Cells on a Soft Hydrogel Substrate
… Prostaglandin E2 (PGE2) when exposed to a fluid shear stress. The exact mechanism by which these cells sense mechanical stress is not well established. A study of the stresses applied by the osteoblasts, under the influence of PGE2, on a hydrogel provided information regarding …
-
A Passive Microfluidic Device for Buffer Transfer of Cells
… is proposed that uses a textit{passive microfluidic approach} to effectively transfer cells from a growth medium to a desired buffer for downstream cDEP analysis. This eliminates the need for any external fields, expensive equipment, and significantly reduces manual efforts. Computational …
-
Sensory Primary Cilium is a Distinct Signaling Compartment
… that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, …
-
Fluid and structural modeling of the disease-free and atherosclerotic human carotid bifurcation
… element analyses: structure only, rigid walled fluid only and fully coupled fluid-structure interaction, areas of low fluid shear stress and high mechanical strain are identified. These results are compared with experimental evidence collected from the literature as well as histological data of …
-
Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
… link between BBB phenotype and flow-associated shear stress. In this regard, our research has demonstrated that exposure of BBMvEC’s to physiological levels of shear stress in vitro can upregulate tight junction protein expression and enhance protein immunolocalization at the cell-cell border, …
Page 1 of 2