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Showing 1 to 7 of 7 for “"flow perfusion"”.
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… polymeric scaffolds in combination with a flow perfusion bioreactor. First, we investigated the effects of flow perfusion on a 3D culture of Ewing sarcoma (ES) cells. We found that increasing levels of flow-derived shear stress promoted the secretion of insulin-like growth factor-1 (IGF-1) …
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Bioluminescence Imaging Strategies for Tissue Engineering Applications
… construct. This research describes the design of flow perfusion bioreactor system suitable for bioluminescence imaging. In the first experimental chapter, the system was tested using MC3T3-E1 cells transfected with a constitutive bioluminescent reporter. It was found that bioluminescence imaging …
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Method for Evaluating Changing Blood Perfusion
… insight into methods for estimating blood perfusion, emphasizing the need for accurate modeling in dynamic physiological environments. The thesis critically examines conventional error function solutions used in steady state or gradually changing blood flow scenarios, revealing their …
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Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
… Since physical signals affect cellular activity, flow perfusion culture was employed to deposit mineralized extracellular matrix (ECM) with different maturity and composition on electrospun poly([varepsilon]-caprolactone) (PCL) microfibers in fabricating mineralized PCL/ECM composite scaffolds. …
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Modulation of the osteoblastic differentiation of marrow stromal cells for bone tissue engineering
… potential of ECM constructs generated in a flow perfusion bioreactor for different peroids of time were tested in an ectopic site in a rodent model. No osteoinduction was observed although an increase in the number of blood vessels within the implants with increasing ECM was noted. This …
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Local Control of Blood Flow in the Bronchial Circulation of Dogs
The bronchial circulation supplies nutritive flow to the conducting airways.I studied the local control of blood flow in the bronchial circulation of dogs. The three aims of my study of the bronchial circulation were to determine: 1) distribution of blood flow from the right bronchial artery: 2) …
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Development of an In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources
… at 7.5x10^5 cells/cm^2 followed by trans-luminal flow for 30 minutes. HUVECs were subsequently trans-luminally pressure sodded at 5.0x10^5 cells/cm^2 followed by an additional 30 minutes of trans-luminal flow; perfusion flow began following the final 30 minutes of trans-luminal flow. Experiments …