Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"floor plate"”.
-
Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… a ventrally located signaling center, the medial floor plate (MFP). Currently, the origin and time frame of specification of this important organizer are not clear. During my PhD thesis, I have analyzed the function of the novel secreted growth factor Midkine-a (Mdka) in zebrafish. In higher …
-
Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors Dcc and Neogenin
… commissural axons to the midline, with the floor plate being a major source of diffusible Netrin. However, this view has recently been challenged. To address this controversy and determine what role, if any, floor plate-derived Netrin-1 plays in commissural axon guidance, we quantitatively …
-
The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… in the ventral midline of the embryo, namely the floor plate and the notochord. In recent years, a lot of research has been carried out to understand how cells interpret the Shh signal and translate this information in order to adopt a specific neuronal fate.<br/><br/>The Notch pathway plays a …
-
Notch signalling in spinal cord patterning: Crosstalk and fate decisions
… the Notch signalling dynamics of the lateral floor plate domain. This reveals that different cell types in the lateral floor plate display discrete durations of Notch signalling. It is the duration of Notch signalling that instructs cell fate determination, as prolonged exposure is required …
-
Form follows finance? ...finance follows form?
… with the structural form, aesthetics and floor plate requirements commonly requested by such firms.
-
Shear analysis of rectangular concrete tanks considering interaction of plate elements
… at any point within a one, two, or three plate system where plates are joined at ninety degree angles. Program options allow for tapered walls and combinations of both uniform and triangular loads for each type plate problem. The three plate solution process automatically imposes boundary …
-
Autotaxin: A Regulator of Oligodendrocyte Differentiation
… atx was found expressed by cells of the cephalic floor plate in addition to differentiating oligodendrocytes. Functionally the in vivo data presented in this dissertation confirmed ATX’s role in stimulating mbp expression during later stages of oligodendrocyte development. In addition, a novel …
-
Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… two signalling centers, the notochord and the floor plate, where it functions as a morphogen to induce early dorso-ventral patterning of the cenral nervous system (CNS). More recently, multiple actions of Shh during CNS development have been discovered in additional sites, where it specifies …
-
Hyperdensity : revival of social fabric
… for insertion of civic programs. Oblique floor plates are introduced as an architectural terrain to operate and negotiate between two systems, the social and the commercial. With each system inherits its own set of distinct floor heights and programmatic parameters, discrepancies between 5 …
-
Identification and characterisation of novel zebrafish brain development mutants obtained by large-scale forward mutagenesis screening
… organisms suggested a role of factors from the floor plate and the MHB in induction of the serotonergic neurons in the hindbrain, and using broken heart, I show that Fgf molecules such as Fgf4 and Fgf8 can restore partially the loss of serotonergic neurons in the mutant. I conclude that forward …
-
Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum
… sonic hedgehog (Shh) is expressed in the floor plate in both the differentiated and the regenerating cord. Using a chemical inhibitor (cyclopamine) and an activator of the hedgehog pathway, I discovered that hedgehog signaling is required for overall tail regeneration. Blocking hedgehog …